TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.176
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) results from leukemic transformation of T-cell precursors arrested at specific differentiation stages, including an ‘early-cortical’ thymic maturation arrest characterized by expression of cytoplasmic TCRβ but no surface T-cell receptor (TCR)… read more here.
Keywords: tcr rearrangements; associated favorable; favorable outcome; expression ... See more keywords
TCRβ rearrangements without a D segment are common, abundant, and public
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2104367118
Abstract: Significance The human body detects foreign pathogens by T cells with specific receptors. These are not directly encoded in the genome but generated in a random process that combines small gene segments into functional subunits… read more here.
Keywords: rearrangements without; without segment; tcr rearrangements; segment ... See more keywords