T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Communications"
DOI: 10.1002/cac2.12074
Abstract: T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).… read more here.
Keywords: methodology; analysis; repertoire; tcr repertoire ... See more keywords
TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0120-427rr
Abstract: The Vγ9Vδ2 T cell subset is the major γδ T cell subset in human peripheral blood and has the unique ability to contribute to immune surveillance by detecting pyrophosphorylated metabolites of isoprenoid synthesis, termed phosphoantigens… read more here.
Keywords: pag; tcr repertoire; neonatal cells; proliferation ... See more keywords
Peripheral blood T-cell receptor repertoire as a predictor of clinical outcomes in gastrointestinal cancer patients treated with PD-1 inhibitor
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02562-4
Abstract: Identifying valid biomarkers for patient selection impressively promotes the success of anti-PD-1 therapy. However, the unmet need for biomarkers in gastrointestinal (GI) cancers remains significant. We aimed to explore the predictive value of the circulating… read more here.
Keywords: clinical outcomes; diversity; cell receptor; repertoire ... See more keywords
In vitro co-culture model of human monocyte-derived dendritic cells and T cells to evaluate the sensitization of dinitrochlorobenzene.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112331
Abstract: Exposure to sensitizer has been suggested to be hazardous to human health, evaluation the sensitization of sensitizer is particularly important and urgently needed. Dendritic cells (DCs) exert an irreplaceable function in immunity, and the T… read more here.
Keywords: dcs; model; dendritic cells; culture model ... See more keywords
LOC440416lncRNA‐Mediated Cell Cycle Arrest Regulated Crizotinib‐Induced Hepatotoxicity: P098
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.10.111
Abstract: Background: Radiotherapy (RT) is a highly effective anti-cancer treatment forming the standard strategies for brain metastasis in non-small cell lung cancer (NSCLC) patients, but local and distal disease recurrence remains a major cause of mortality.… read more here.
Keywords: tcr repertoire; brain; cell; lung lesions ... See more keywords
No difference in TCRβ repertoire of CD4+ naive T cell between patients with primary biliary cholangitis and healthy control subjects.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.09.019
Abstract: Primary biliary cholangitis (PBC) is considered as a model of organ-specific autoimmune disease based on the serological findings of anti-mitochondrial antibodies (AMA), infiltrates of T cells, and selective destruction of epithelial cells in the liver.… read more here.
Keywords: primary biliary; selection; repertoire; biliary cholangitis ... See more keywords
Deciphering the TCR Repertoire to Solve the COVID-19 Mystery
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Pharmacological Sciences"
DOI: 10.1016/j.tips.2020.06.001
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while… read more here.
Keywords: repertoire solve; covid; tcr repertoire; deciphering tcr ... See more keywords
GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses
Sign Up to like & getrecommendations! Published in 2017 at "Bone Marrow Transplantation"
DOI: 10.1038/bmt.2016.305
Abstract: Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic leukemia (T-PLL). However, direct evidence of GvL activity in T-PLL is lacking. We correlated minimal residual disease (MRD) kinetics with immune interventions and… read more here.
Keywords: mrd; mrd kinetics; evidence; prolymphocytic leukemia ... See more keywords
Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2016.71
Abstract: Epstein‐Barr virus (EBV) is one of the most common viruses in humans, capable of causing life‐threatening infections and cancers in immunocompromised individuals. Although CD8+ T cells provide key protection against EBV, the persistence and dynamics… read more here.
Keywords: tcr repertoire; specific cd8; tcr; transplant ... See more keywords
The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02373c
Abstract: Isoglobotrihexosylceramide (iGb3) is a known NKT cell agonist, however the specific interactions required to trigger NKT cell TCR activation in response to this mammalian glycolipid are not fully understood. Here we report the synthesis of… read more here.
Keywords: nkt cell; tcr repertoire; cell tcr; igb3 ... See more keywords
Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2019.1647350
Abstract: Abstract Purpose: To characterize the T cell receptor (TCR) repertoire, serum cytokine levels, peripheral blood T lymphocyte populations, safety, and clinical efficacy of hyperthermia (HT) combined with autologous adoptive cell therapy (ACT) and either salvage… read more here.
Keywords: solid tumors; adoptive cell; peripheral blood; tcr repertoire ... See more keywords