On the viability of unsupervised T-cell receptor sequence clustering for epitope preference
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty821
Abstract: MOTIVATION The T-cell receptor (TCR) is responsible for recognizing epitopes presented on cell surfaces. Linking TCR sequences to their ability to target specific epitopes is currently an unsolved problem, yet one of great interest. Indeed,… read more here.
Keywords: tcr sequences; cell receptor; cell; sequence ... See more keywords
T Cell Receptor Sequences Amplified during Severe COVID-19 and Multisystem Inflammatory Syndrome in Children Mimic SARS-CoV-2, Its Bacterial Co-Infections and Host Autoantigens
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021335
Abstract: Published hypervariable region V-beta T cell receptor (TCR) sequences were collected from people with severe COVID-19 characterized by having various autoimmune complications, including blood coagulopathies and cardiac autoimmunity, as well as from patients diagnosed with… read more here.
Keywords: severe covid; tcr sequences; multisystem inflammatory; cell receptor ... See more keywords
The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes
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DOI: 10.7554/elife.49900
Abstract: The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using… read more here.
Keywords: repertoire; cell; cell receptor; tcr sequences ... See more keywords