TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0544-5
Abstract: High-throughput 3′ single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell… read more here.
Keywords: seq; scrna seq; sequencing paired; tcr sequencing ... See more keywords
iCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencing
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.27214.2
Abstract: The pathogen exposure history of an individual is recorded in their T-cell repertoire and can be accessed through the study of T-cell receptors (TCRs) if the tools to identify them were available. For each T-cell,… read more here.
Keywords: tcr sequencing; tool; immunological history; icat ... See more keywords