Investigating T Cell Receptor Signals In Situ by Two-Photon Microscopy of Thymocytes Expressing Genetic Reporters in Low-Density Chimeras.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0266-9_18
Abstract: T cell development is a dynamic process accompanied by extensive thymocyte migration, cellular interactions, and T cell receptor (TCR) signaling. In particular, thymic selection processes that ensure a functional, self-tolerant repertoire require TCR interactions with… read more here.
Keywords: microscopy; two photon; tcr signaling; cell ... See more keywords
TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.081
Abstract: TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different… read more here.
Keywords: cells riii; riii; riii induced; induced tcr ... See more keywords
Erythroid differentiation regulator 1 strengthens TCR signaling in thymocytes by modulating calcium flux.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.12.004
Abstract: Erythroid differentiation regulator 1 (Erdr1) has been identified as a stromal survival factor released under stressful conditions. Previously, Erdr1 was reported to be expressed highly in thymus, but roles of Erdr1 in thymus were not… read more here.
Keywords: tcr signaling; erdr1; differentiation regulator; erythroid differentiation ... See more keywords
TCR Signaling: Mechanisms of Initiation and Propagation.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2017.11.008
Abstract: The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A hallmark of the T… read more here.
Keywords: tcr signaling; mechanisms initiation; signaling mechanisms; initiation propagation ... See more keywords
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Nature immunology"
DOI: 10.1038/s41590-018-0103-5
Abstract: Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells. Nup210-deficient CD4+ T lymphocytes… read more here.
Keywords: cell homeostasis; tcr signaling; cd4 cell; cell ... See more keywords
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0732-3
Abstract: Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate signaling is not well known. We report… read more here.
Keywords: cd3; lck; function; binding lck ... See more keywords
THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.ade1274
Abstract: The T cell lineage–restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the activity of the tyrosine phosphatase… read more here.
Keywords: cd4 cd8; themis; tcr signaling; selection ... See more keywords
Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005845
Abstract: Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs) (such as PD-1 and CTLA4) can limit T cell receptor (TCR) signal propagation in… read more here.
Keywords: cell receptor; tcr signaling; receptor tcr; immunotherapy ... See more keywords
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function
Sign Up to like & getrecommendations! Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201800282
Abstract: Costimulation of T cells through both TCR and STING induces growth inhibition by partially blocking the mTORC1 signals, and leads to IFN-I production through sustained activation of IRF3 and mTORC1 activation. Stimulator of interferon genes… read more here.
Keywords: sting tcr; mtorc1; ifn production; activation ... See more keywords
Coreceptors and TCR Signaling – the Strong and the Weak of It
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.597627
Abstract: The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses by many orders of magnitude… read more here.
Keywords: cd4 cd8; coreceptors tcr; tcr signaling; cell ... See more keywords
Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.608747
Abstract: Early TCR signaling is dependent on rapid phosphorylation and dephosphorylation of multiple signaling and adaptor proteins, leading to T cell activation. This process is tightly regulated by an intricate web of interactions between kinases and… read more here.
Keywords: tyrosine phosphatases; early tcr; autoimmunity; tcr signaling ... See more keywords