Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.011
Abstract: Functional characterisation of different HIV-1 subtypes may improve understanding of viral pathogenesis and spread. Here, we evaluated the ability of 345 unique HIV-1 Nef clones representing subtypes A, B, C and D to inhibit NFAT… read more here.
Keywords: nef clones; nef mediated; tcr stimulation; hiv subtypes ... See more keywords
Flotillin-2 dampens T cell antigen sensitivity and functionality
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DOI: 10.1172/jci.insight.182328
Abstract: T cell receptor (TCR) engagement triggers T cell responses, yet how TCR-mediated activation is regulated at the plasma membrane remains unclear. Here, we report that deleting the membrane scaffolding protein Flotillin-2 (Flot2) increases T cell… read more here.
Keywords: antigen sensitivity; weak tcr; cell; sensitivity ... See more keywords