Enhancer dependent repositioning of TCRb locus with respect to the chromosome territory.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167509
Abstract: Intranuclear position of several genes is dynamically altered during development concordant with their activation. To understand this dynamic, but non-random, nuclear organization, it is important to identify the relevant regulatory elements and trans acting factors.… read more here.
Keywords: tcrb locus; enhancer; chromosome territory;
Site Specific and Orientation Dependent CTCF Binding Determines VDJ Recombination at Murine Tcrb Locus
Sign Up to like & getrecommendations! Published in 2025 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2025.2553650
Abstract: Abstract CTCF is a multifunctional protein that mediates long-range cis-DNA interactions in mammalian genomes. Chromatin architecture governs spatial and functional interactions of gene regulatory elements at various loci and is impacted by the ability of… read more here.
Keywords: ctcf binding; recombination; vdj recombination; tcrb locus ... See more keywords