Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2017.2007
Abstract: Importance Adolescents represent a key population for implementing preexposure prophylaxis (PrEP) interventions worldwide, yet tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for PrEP is only licensed for adults. Objective To examine the safety of and adherence to PrEP… read more here.
Keywords: medicine; prep; safety; tdf ftc ... See more keywords
Pharmacokinetic Interactions Between the Fixed‐Dose Combinations of Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Elbasvir/Grazoprevir in Healthy Adult Participants
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.702
Abstract: Treatment of individuals coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) requires careful consideration of potential drug‐drug interactions. The pharmacokinetic interaction of the HCV fixed‐dose combination treatment of elbasvir/grazoprevir (EBR/GZR) when coadministered… read more here.
Keywords: cob tdf; tdf ftc; ebr gzr; evg cob ... See more keywords
Efficacy and safety of long-acting cabotegravir versus oral tenofovir disoproxil fumarate-emtricitabine as HIV pre-exposure prophylaxis: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Reviews in medical virology"
DOI: 10.1002/rmv.2460
Abstract: WHO guidelines recommend daily oral tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) of HIV in people at high risk of HIV infection. However, due to social, psychological and other reasons, the… read more here.
Keywords: meta analysis; hiv; acting cabotegravir; long acting ... See more keywords
Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals
Sign Up to like & getrecommendations! Published in 2018 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-018-0194-1
Abstract: IntroductionTenofovir disoproxil fumarate (TDF) has been associated with greater incidences of bone complications, which might be modified by some concomitantly administered antiretrovirals, possibly by their effect on tenofovir concentrations. We compared bone adverse outcomes among… read more here.
Keywords: ftc; bone; tdf ftc; efv ... See more keywords
Short Communication: Bioequivalence of Tenofovir and Emtricitabine After Coencapsulation with the Proteus Ingestible Sensor.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2018.0081
Abstract: Adherence to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC, Truvada®) is the primary determinant of HIV pre-exposure prophylaxis (PrEP) efficacy. Despite its importance, limitations exist in current methods of adherence quantification, restricting their implementation in the clinic. Proteus… read more here.
Keywords: bioequivalence; tenofovir; ingestible sensor; proteus ... See more keywords
Use of generic antiretroviral drugs and single-tablet regimen de-simplification for the treatment of HIV infection in Spain.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2021.0122
Abstract: The present study sought describe the use of generic drugs and single-tablet regimen (STR) de-simplification for the treatment of HIV infection among 41 hospitals from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). In… read more here.
Keywords: tdf ftc; single tablet; drugs single; tdf ... See more keywords
Costs and benefits of on-demand HIV preexposure prophylaxis in MSM.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001658
Abstract: OBJECTIVES We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial, which showed the efficacy of on-demand preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-emtricitabine (FTC) in preventing HIV infection among high-risk MSM. DESIGN… read more here.
Keywords: hiv infection; infection; tdf ftc; demand prep ... See more keywords
Similar tenofovir hair concentrations in men and women after directly-observed: dosing of TDF/FTC: implications for PrEP adherence monitoring.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001935
Abstract: OBJECTIVES Women likely require higher adherence than men to pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for similar efficacy. Pharmacologic metrics of adherence predict efficacy better than self-report, but expected drug levels (adherence… read more here.
Keywords: hair concentrations; hair; tenofovir hair; tdf ftc ... See more keywords
Daily or on demand oral TDF/FTC for HIV pre-exposure prophylaxis: experience from an hospital-based clinic in France.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001939
Abstract: BACKGROUND On Demand oral TDF/FTC has been approved for pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) in France following the results of clinical studies but data are limited on real-world experience.… read more here.
Keywords: oral tdf; exposure prophylaxis; tdf ftc; demand oral ... See more keywords
Extended Analysis of HIV Infection in Cisgender Men and Transgender Women Who Have Sex with Men Receiving Injectable Cabotegravir for HIV Prevention: HPTN 083
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00053-23
Abstract: HPTN 083 demonstrated that injectable cabotegravir (CAB) was superior to oral tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) for HIV prevention in cisgender men and transgender women who have sex with men. We previously analyzed 58 infections in… read more here.
Keywords: hptn 083; hiv; arm; cab ... See more keywords
A public health approach to monitoring HIV with resistance to HIV pre-exposure prophylaxis
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DOI: 10.1371/journal.pone.0272958
Abstract: Background The risk of HIV pre-exposure prophylaxis (PrEP) failure with sufficient medication adherence is extremely low but has occurred due to transmission of a viral strain with mutations conferring resistance to PrEP components tenofovir (TDF)… read more here.
Keywords: ftc resistance; tdf ftc; resistance; hiv ... See more keywords