The TDP‐43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402913
Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies with a 5‐year survival rate of only 15% in patients with advanced diseases. Tumor protein 63 (TP63), a master transcription factor (TF) in… read more here.
Keywords: esophageal squamous; tp63; cell carcinoma; squamous cell ... See more keywords
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
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DOI: 10.1002/advs.202412054
Abstract: Cytoplasmic aggregation of transactive response DNA‐binding protein 43 (TDP‐43) is a hallmark of amyotrophic lateral sclerosis (ALS) and occurs in 57% of Alzheimer's disease (AD) cases. TDP‐43 regulates RNA processing, including cryptic exon splicing. Here,… read more here.
Keywords: cryptic splicing; gap43; hallmark tdp; cryptic exon ... See more keywords
BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202505635
Abstract: Biogenesis of lysosome‐related organelles complex 1 subunit 1 (BLOC1S1) is considered to have anti‐Brucella potential. However, the effect of BLOC1S1 on Brucella autophagy has not yet been studied. This study investigates the interplay between Brucella… read more here.
Keywords: melitensis 16m; bloc1s1; 16m lps; autophagy ... See more keywords
TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of neurology"
DOI: 10.1002/ana.78012
Abstract: OBJECTIVE Mutations in TARDBP (encoding TDP-43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.… read more here.
Keywords: spinal cord; cord motor; tdp; motor ... See more keywords
Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200181
Abstract: The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of… read more here.
Keywords: tug war; aggregation; keep tdp; importin tug ... See more keywords
Plasma TDP-43 Reflects Cortical Neurodegeneration and Correlates with Neuropsychiatric Symptoms in Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-022-01150-5
Abstract: Huntington’s disease (HD) is a monogenic neurodegenerative disease with no effective treatment currently available. The pathological hallmark of HD is the aggregation of mutant huntingtin in the medium spiny neurons of the striatum, leading to… read more here.
Keywords: huntington disease; plasma tdp; tdp; neuropsychiatric symptoms ... See more keywords
Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin–dopamine antagonists against insomnia and nocturnal delirium
Sign Up to like & getrecommendations! Published in 2019 at "Heart and Vessels"
DOI: 10.1007/s00380-019-01521-y
Abstract: Torsade de pointes (TdP) occurred in a long QT syndrome type 3 (LQT3) patient after switching perospirone to blonanserin. We studied how their electropharmacological effects had induced TdP in the LQT3 patient. Perospirone hydrochloride (… read more here.
Keywords: heart; perospirone; tdp; total peripheral ... See more keywords
Co-occurrence of mixed proteinopathies in late-stage Huntington’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1786-7
Abstract: Accumulating evidence highlights the potential role of mixed proteinopathies (i.e., abnormal protein aggregation) in the development of clinical manifestations of neurodegenerative diseases (NDD). Huntington’s disease (HD) is an inherited NDD caused by autosomal-dominant expanded CAG… read more here.
Keywords: aggregation; mixed proteinopathies; tdp; huntington disease ... See more keywords
Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1875-2
Abstract: Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical finding in almost all ALS patients, more than half of FTLD patients and patients with several other neurodegenerative disorders. It appears that perturbation of nucleo-cytoplasmic transport is… read more here.
Keywords: tdp; motor neurons; transport; nucleo cytoplasmic ... See more keywords
Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02070-4
Abstract: Frontotemporal lobar degeneration with TDP-43 immunoreactive (TDP-ir) inclusions (FTLD-TDP) is sub-classified based on the pattern of neocortical pathology, with each subtype showing clinical and genetic correlations. Recent studies indicate that accurate subtyping of cases may… read more here.
Keywords: tdp; subcortical tdp; pathology; ftld tdp ... See more keywords
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02205-y
Abstract: Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to… read more here.
Keywords: neuronal axons; protein; local translation; tdp ... See more keywords