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Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.05.021
Abstract: TDP-43 is a major disease-causing protein in amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). Today, >50 missense mutations in the TARDBP/TDP-43 gene have been described in patients with FTLD/ALS. However, the functional consequences…
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Keywords:
protein;
linked tdp;
tdp mutations;
als linked ... See more keywords
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Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.611601
Abstract: Amyotrophic Lateral Sclerosis (ALS) is characterized by degeneration of motor neurons in the brain and spinal cord. Cytoplasmic inclusions of TDP-43 are frequently reported in motor neurons of ALS patients. TDP-43 has also been shown…
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Keywords:
mutant tdp;
motoneuron like;
tdp;
tdp mutations ... See more keywords