TDP‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy
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DOI: 10.1002/ana.26438
Abstract: Primary age‐related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of significant beta‐amyloid plaques. PART has been associated with cognitive impairment, but contributions from concomitant limbic… read more here.
Keywords: tdp pathology; age related; primary age; related tauopathy ... See more keywords
Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.08.009
Abstract: &NA; Oxidative stress is recognised as central in a range of neurological diseases including Amyotrophic lateral sclerosis (ALS), a disease characterised by fast progressing death of motor neurons in the brain and spinal cord. Cellular… read more here.
Keywords: gsh; pathology; tdp pathology; motor ... See more keywords
Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1101/2022.05.05.490760
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43) within… read more here.
Keywords: pathogenic tdp; tdp pathology; pathology; cerebral organoids ... See more keywords
Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts
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DOI: 10.1111/bpa.12773
Abstract: Limbic‐predominant age‐related TAR‐DNA‐binding protein‐43 (TDP‐43) encephalopathy with hippocampal sclerosis pathology (LATE‐NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP‐43‐pathology, leading to cognitive dysfunction and dementia. Polymorphisms in GRN,… read more here.
Keywords: risk; hippocampal sclerosis; pathology; tmem106b ... See more keywords
Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
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DOI: 10.1111/bpa.13100
Abstract: This study aimed to assess and compare the burden of transactive response DNA‐binding protein of 43 kDa (TDP‐43) pathology and clinical features of amyotrophic lateral sclerosis (ALS) in three age groups. All cases were from… read more here.
Keywords: tdp pathology; age; pathology; lateral sclerosis ... See more keywords
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
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DOI: 10.1126/science.abq7860
Abstract: Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 (TBK1) gene. We found that TBK1 is phosphorylated in response… read more here.
Keywords: tdp pathology; endosomal pathway; pathology; pathway ... See more keywords
A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.868556
Abstract: Neuronal cytoplasmic aggregation and ubiquitination of TDP-43 is the most common disease pathology linking Amyotrophic Lateral Sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 pathology is characterized by the presence of low molecular weight TDP-43… read more here.
Keywords: truncated tdp; tdp pathology; terminally truncated; sequence ... See more keywords
TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients
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DOI: 10.3390/biomedicines10020385
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau protein and β-amyloid), their translation… read more here.
Keywords: tdp pathology; alzheimer disease; patients diagnosed; pathology ... See more keywords
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67587
Abstract: Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although defects in nucleocytoplasmic transport (NCT) is… read more here.
Keywords: pathology; nucleocytoplasmic transport; traumatic injury; tdp pathology ... See more keywords