TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.245811
Abstract: ABSTRACT In >95% of cases of amyotrophic lateral sclerosis (ALS) and ∼45% of frontotemporal degeneration (FTD), the RNA/DNA-binding protein TDP-43 is cleared from the nucleus and abnormally accumulates in the cytoplasm of affected brain cells.… read more here.
Keywords: tdp; amyotrophic lateral; tankyrase; tdp protein ... See more keywords
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126829
Abstract: Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of ALS patients, including those carrying the… read more here.
Keywords: deficiency insufficiency; protein; tdp protein; optn470t microglia ... See more keywords