The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64541-5
Abstract: Candidate PET ligands targeting pathological TDP-43 aggregates are characterized by Vokali and colleagues in a series of human tissue, cell/animal model, and non-human primate experiments. Their preclinical data suggests favorable specificity and pharmacokinetic profiles of… read more here.
Keywords: potential tdp; tdp proteinopathies; tdp; pet ligands ... See more keywords
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-025-00859-4
Abstract: Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein and RNA that reflect the type and status of their… read more here.
Keywords: extracellular vesicles; vesicles tdp; tdp proteinopathies; pathogenesis ... See more keywords
Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.931968
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. About 15% cases of ALS also develop the frontotemporal dementia (FTD), in which… read more here.
Keywords: ubiquitinating deubiquitinating; tdp proteinopathies; deubiquitinating mechanisms; implication ubiquitinating ... See more keywords
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.840357
Abstract: Local control of gene expression provides critical mechanisms for regulating development, maintenance and plasticity in the nervous system. Among the strategies known to govern gene expression locally, mRNA transport and translation have emerged as essential… read more here.
Keywords: tdp proteinopathies; dysregulation translation; tdp; translation ... See more keywords