α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.06.013
Abstract: The antiepileptic drug ethosuximide has recently been shown to be neuroprotective in various Caenorhabditis elegans and rodent neurodegeneration models. It is therefore a promising repurposing candidate for the treatment of multiple neurodegenerative diseases. However, high… read more here.
Keywords: methyl phenylsuccinimide; phenylsuccinimide ameliorates; ameliorates neurodegeneration; neurodegeneration elegans ... See more keywords
Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71305-2
Abstract: Alzheimer’s disease patients typically present with multiple co-morbid neuropathologies at autopsy, but the impact of these pathologies on cognitive impairment during life is poorly understood. In this study, we developed cognitive trajectories for patients with… read more here.
Keywords: alzheimer disease; disease; disease neuropathology; cognitive impairment ... See more keywords
Targeting TDP‐43 proteinopathy with drugs and drug‐like small molecules
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15148
Abstract: Following the discovery of the involvement of the ribonucleoprotein TDP‐43 in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research focus has been to develop treatments that can prevent or alleviate these… read more here.
Keywords: drugs drug; proteinopathy drugs; tdp; small molecules ... See more keywords
Mechanisms of TDP-43 Proteinopathy Onset and Propagation
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DOI: 10.3390/ijms22116004
Abstract: TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a number of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. While mutations in the TARDBP gene that codes for… read more here.
Keywords: pathogenesis; onset propagation; tdp proteinopathy; mechanisms tdp ... See more keywords
TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
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DOI: 10.3390/ijms232415755
Abstract: Transactivation response DNA binding protein 43 kDa (TDP-43) and tau are major pathological proteins of neurodegenerative disorders, of which neuronal and glial aggregates are pathological hallmarks. Interestingly, accumulating evidence from neuropathological studies has shown that… read more here.
Keywords: tauopathy pathomechanistic; pathology; tdp proteinopathy; pathomechanistic links ... See more keywords
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12020101
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal, complex neurodegenerative disorder that causes selective degeneration of motor neurons. ALS patients exhibit symptoms consistent with altered cellular energetics such as hypermetabolism, weight loss, dyslipidemia, insulin resistance, and… read more here.
Keywords: drosophila models; cycle; tca cycle; dopamine levels ... See more keywords