Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons
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DOI: 10.3389/fcell.2022.876893
Abstract: Mutations in TDP-43, a RNA-binding protein with multiple functions in RNA metabolism, cause amyotrophic lateral sclerosis (ALS), but it is uncertain how defects in RNA biology trigger motor neuron degeneration. TDP-43 is a major constituent… read more here.
Keywords: tdp rnp; helical domain; transport; determinants tdp ... See more keywords