TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
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DOI: 10.1038/s41467-017-00307-y
Abstract: DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous… read more here.
Keywords: transcription; tdp2 suppresses; gene transcription; topoisomerase ... See more keywords