Neural Progenitor Cells Undergoing Yap/Tead-Mediated Enhanced Self-Renewal Form Heterotopias More Easily in the Diencephalon than in the Telencephalon
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2390-x
Abstract: Spatiotemporally ordered production of cells is essential for brain development. Normally, most undifferentiated neural progenitor cells (NPCs) face the apical (ventricular) surface of embryonic brain walls. Pathological detachment of NPCs from the apical surface and… read more here.
Keywords: neural progenitor; progenitor cells; tead; yap tead ... See more keywords
Abstract 3401: Discovery of GH658, a novel tead allosteric inhibitor as a cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3401
Abstract: The Hippo pathway is an evolutionarily conserved signaling cascade. Its dysregulation may lead to cancer progression, metastasis, cancer therapy resistance, and immune evasion. Diverse genetic aberrations leading to YAP/TAZ hyperactivation have been elucidated over the… read more here.
Keywords: tead; gh658; gh658 novel; cancer therapy ... See more keywords
Abstract 4976: Preclinical characterization of BGI-9004, a covalent TEAD inhibitor with exceptional anti-cancer activity and combination potential
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4976
Abstract: Pharmacological inhibitors of TEAD transcription factors have emerged as a promising novel class of anti-cancer agents. TEAD inhibitors disrupt oncogenic YAP/TAZ signaling, resulting in cell cycle arrest and cell death in susceptible cancers. In preclinical… read more here.
Keywords: anti cancer; tead; activity; bgi 9004 ... See more keywords
Abstract 6377: TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6377
Abstract: The Hippo signaling pathway is a major regulator of cellular growth and is frequently deregulated in cancer. TEAD proteins are the main transcriptional effectors of the Hippo pathway and a pharmacological target in oncology. Most… read more here.
Keywords: hippo pathway; tead; tead targeting; vgll4 ... See more keywords
Abstract A043: p53 licenses transcriptional regulation by TEAD to dictate cell fate in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic25-a043
Abstract: Activity of the tumor suppressor p53 defines the pre-malignant to malignant transition in more than half of pancreatic ductal adenocarcinoma (PDAC). How p53 determines these molecularly distinct expression and cell fate landscapes remains poorly understood.… read more here.
Keywords: cancer; tead; p53; cell ... See more keywords
Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models
Sign Up to like & getrecommendations! Published in 2023 at "Plants"
DOI: 10.3390/plants12010206
Abstract: Atriplex dimorphostegia (Saltbush) is an annual halophytic shrub that is widely distributed across various parts of Asia. The current study is the first to report the metabolites profile of the total ethanol extract of the… read more here.
Keywords: uplc pda; tead; silico vivo; anabolic effect ... See more keywords