EXTH-51. ANTI-INVASIVE EFFICACY AND SURVIVAL BENEFIT OF THE YAP-TEAD INHIBITOR VERTEPORFIN IN PRECLINICAL GLIOBLASTOMA MODELS
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DOI: 10.1093/neuonc/noaa215.405
Abstract: Glioblastoma (GBM) remains an incurable disease, in large part due to its malignant infiltrative spread, and current clinical therapy fails to target the invasive nature of tumor cells in disease progression and recurrence. Here, we… read more here.
Keywords: tumor; survival benefit; gbm; yap tead ... See more keywords
Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers
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DOI: 10.1158/1538-7445.am2023-1646
Abstract: The Hippo signaling cascade regulates cell proliferation and survival, as well as overall tissue homeostasis. These functions are mediated by the TEAD family of transcription factors which, when bound to the co-activators YAP or TAZ,… read more here.
Keywords: tead inhibitor; taz tead; yap taz; inhibitor ... See more keywords
Abstract 4491: TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo
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DOI: 10.1158/1538-7445.am2023-4491
Abstract: Hippo/YAP pathway plays an essential role in cell proliferation, tissue regeneration, and tumorigenesis. The emerging evidence shows that hyperactivation of the Hippo/YAP pathway induces metastasis, chemoresistance, and the attribute of cancer stem cells. Dysregulated Hippo/YAP… read more here.
Keywords: inhibitor; yap tead; yap; tead inhibitor ... See more keywords
Abstract 7264: OPN-9840, a non-covalent potent pan-TEAD inhibitor, exhibits single agent efficacy in preclinical malignant mesothelioma models
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DOI: 10.1158/1538-7445.am2024-7264
Abstract: The Hippo pathway regulates critical cellular processes during development. In ~10% of human cancers, Hippo pathway dysregulation results in YAP/TAZ overactivation and increased TEAD-dependent transcription that promotes tumor growth and therapy resistance - often by… read more here.
Keywords: covalent; pan; pan tead; tead inhibitor ... See more keywords