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Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.405
Abstract: Glioblastoma (GBM) remains an incurable disease, in large part due to its malignant infiltrative spread, and current clinical therapy fails to target the invasive nature of tumor cells in disease progression and recurrence. Here, we…
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Keywords:
tumor;
survival benefit;
gbm;
yap tead ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1646
Abstract: The Hippo signaling cascade regulates cell proliferation and survival, as well as overall tissue homeostasis. These functions are mediated by the TEAD family of transcription factors which, when bound to the co-activators YAP or TAZ,…
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Keywords:
tead inhibitor;
taz tead;
yap taz;
inhibitor ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4491
Abstract: Hippo/YAP pathway plays an essential role in cell proliferation, tissue regeneration, and tumorigenesis. The emerging evidence shows that hyperactivation of the Hippo/YAP pathway induces metastasis, chemoresistance, and the attribute of cancer stem cells. Dysregulated Hippo/YAP…
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Keywords:
inhibitor;
yap tead;
yap;
tead inhibitor ... See more keywords