SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy
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DOI: 10.1002/advs.202305677
Abstract: Pathological cardiac hypertrophy is the leading cause of heart failure and has an extremely complicated pathogenesis. TEA domain transcription factor 1 (TEAD1) is recognized as an important transcription factor that plays a key regulatory role… read more here.
Keywords: cardiac hypertrophy; hypertrophy; pathological cardiac; sumoylation tead1 ... See more keywords
TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
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DOI: 10.1038/s41392-023-01732-w
Abstract: Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development and homeostasis. However, fibroblast endogenous… read more here.
Keywords: cardiac fibroblasts; brd4 wnt4; cardiac remodeling; tead1 ... See more keywords
Investigating the Effects of AL049796.1 Silencing in Inhibiting High Glucose-Induced Colorectal Cancer Progression
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DOI: 10.1089/dna.2024.0069
Abstract: Patients with colorectal cancer (CRC) and diabetes share many risk factors. Despite a strong association between diabetes and CRC being widely studied and confirmed, further genetic research is needed. This study found higher AL049796.1 and… read more here.
Keywords: al049796 silencing; colorectal cancer; high glucose; crc ... See more keywords
RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling
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DOI: 10.1093/nar/gkac509
Abstract: Abstract Alternative pre-mRNA splicing is key to proteome diversity; however, the biological roles of alternative splicing (AS) in signaling pathways remain elusive. Here, we focus on TEA domain transcription factor 1 (TEAD1), a YAP binding… read more here.
Keywords: rbfox2 regulated; tead1; alternative splicing; yap ... See more keywords
PO-125 FAT1 on salvador-warts-hippo (SWH) pathway in human glioblastoma
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DOI: 10.1136/esmoopen-2018-eacr25.166
Abstract: Introduction Glioblastoma(GBM) is an aggressive brain tumour arising from glial cells. Our lab has identified the oncogenic role of FAT1 gene in GBM, regulating inflammatory and hypoxic microenvironment of the tumour as well as migratory/invasive… read more here.
Keywords: yap1; fat1; tead1; salvador warts ... See more keywords
CircSLC8A1 Exacerbates Hypoxia-Induced Myocardial Injury via Interacting with MiR-214-5p to Upregulate TEAD1 Expression.
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DOI: 10.1536/ihj.21-547
Abstract: Circular RNAs (circRNAs) act as important regulators in myocardial infarction (MI). This study aimed to explore the regulatory mechanism of circRNA solute carrier family 8 member A1 antisense RNA 1 (circSLC8A1) in hypoxia-induced myocardial injury.Exosomes… read more here.
Keywords: hypoxia induced; tead1; circslc8a1; mir 214 ... See more keywords
Dissecting the multi-omics landscape of TEAD1 in hepatocellular carcinoma: cycle regulation and metastatic potential
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DOI: 10.3389/fimmu.2025.1567969
Abstract: Background The effects exerted by the TEA domain transcription factor family genes on tumorigenesis in various cancers have been extensively investigated. Nevertheless, the potential role of TEAD1 in cancer-related epigenetic alterations, immunological characteristics, and prognosis… read more here.
Keywords: cancer; landscape tead1; hepatocellular carcinoma; tead1 ... See more keywords