TEAD4 Is an Immune Regulating-Related Prognostic Biomarker for Bladder Cancer and Possesses Generalization Value in Pan-Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0164
Abstract: Recent studies have revealed the significant role of TEA domain family member 4 (TEAD4) in the development and progression of cancer. However, the potential role of TEAD4 in the progression of bladder cancer (BC) remains… read more here.
Keywords: pan cancer; value; expression; cancer ... See more keywords
O-099 TEAD4 regulates trophectoderm differentiation upstream of CDX2 in human preimplantation embryos
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab125.069
Abstract: What is the main pathway regulating trophectoderm (TE) differentiation during pre-implantation development in mouse versus human embryos? TEAD4 is acting upstream of CDX2 and is involved in TE differentiation, as TEAD4-null human embryos exhibit compromised… read more here.
Keywords: embryos; crispr cas9; differentiation; development ... See more keywords
Tea Domain Transcriptional Factor 4 (TEAD4) mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad010
Abstract: Tea domain transcriptional factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with YAP in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with TGF-β-activated Smad proteins… read more here.
Keywords: transcriptional factor; domain transcriptional; tea domain; factor tead4 ... See more keywords
NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16409
Abstract: 5′‐Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects of which have not been well characterized. This study aimed to investigate the expression profile and functional regulation of NT5DC2 and its potential… read more here.
Keywords: positive feedback; feedback loop; cell growth; unpalmitoylated tead4 ... See more keywords
Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development of the bovine blastocyst.
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DOI: 10.1530/rep-18-0043
Abstract: The first segregation at the blastocyst stage is the symmetry-breaking event to characterize two cell components; namely, inner cell mass (ICM) and trophectoderm (TE). TEA domain transcription factor 4 (TEAD4) is a well-known regulator to… read more here.
Keywords: tead4 ccn2; bovine; expression; blastocyst ... See more keywords
G-quadruplexes formation within the promoter of TEAD4 oncogene and their interaction with Vimentin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1008075
Abstract: G-quadruplexes (G4s) are nucleic acid secondary structures detected within human chromosomes, that cluster at gene promoters and enhancers. This suggests that G4s may play specific roles in the regulation of gene expression. Within a distinct… read more here.
Keywords: tead4; within promoter; vimentin; tead4 oncogene ... See more keywords
A Four-Gene Prognostic Signature Based on the TEAD4 Differential Expression Predicts Overall Survival and Immune Microenvironment Estimation in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.874780
Abstract: Background: TEA domain transcription factor 4 (TEAD4) is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which is studied to be linked to the tumorigenesis and progression of various forms of… read more here.
Keywords: luad; immune microenvironment; risk; microenvironment estimation ... See more keywords