Tear Fluid-Based Metabolomics Profiling in Chronic Dacryocystitis Patients.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00592
Abstract: Chronic dacryocystitis (CD) can result in severe complications and vision impairment due to ongoing microbial infections and persistent tearing. Tear fluid, which contains essential components vital for maintaining ocular surface health, has been investigated for… read more here.
Keywords: based metabolomics; chronic dacryocystitis; fluid based; tear fluid ... See more keywords
Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
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DOI: 10.1038/s41598-021-01993-x
Abstract: There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65… read more here.
Keywords: tau levels; tau; neurodegeneration; tear fluid ... See more keywords
Reference genes validation in tear fluid for RNA analysis in ocular surface disease
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DOI: 10.1038/s41598-025-05638-1
Abstract: Proper normalization of gene expression data is essential for detecting early molecular alterations in eye disorders. In this study, we assessed seven potential reference genes (18S, RER1, ACTB, GAPDH, PGK1, UBC, and AP3D1) in tear… read more here.
Keywords: ocular surface; disease; analysis; reference ... See more keywords
Proteomic profiling of tear fluid from offspring of Keratoconus patients: New insights into pathways and molecular drivers of disease development
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DOI: 10.1111/aos.15827
Abstract: Aims: To analyse the tear proteome of the offspring of Keratoconus (KC) patients in comparison with control subjects, trying to elucidate the molecular drivers underlying the risk of KC development in this population and providing… read more here.
Keywords: keratoconus patients; offspring keratoconus; fluid offspring; development ... See more keywords
miRNAs from tear fluid‐derived extracellular vescicles to identify patients at high risk of fibrotic lesions after glaucoma surgery
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DOI: 10.1111/aos.17123
Abstract: Aims/Purpose: Glaucoma is a progressive optic neuropathy characterized by elevated intraocular pressure (IOP). Initial treatment involves topical medication, but surgical intervention is indicated for patients with uncontrolled IOP (1). Yet, post‐surgical tissue fibrosis is a… read more here.
Keywords: risk; derived extracellular; fluid derived; tear fluid ... See more keywords
Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251326868
Abstract: Background Tear fluid (TF) is a protein-rich solution that reflects pathophysiological changes in Alzheimer's disease (AD). Objective In this study, we examined whether TF proteins were differently expressed in persons with mild AD dementia compared… read more here.
Keywords: alzheimer disease; disease; protein; expression ... See more keywords
A preliminary proteomic analysis of tear fluid in patients with high myopia
Sign Up to like & getrecommendations! Published in 2025 at "BMC Ophthalmology"
DOI: 10.1186/s12886-025-04129-1
Abstract: Using liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a protein quantification technique for the analysis of the proteomic profile of myopia patient tear fluid, to clarify the role of dysregulated proteins in high myopia (HM) in… read more here.
Keywords: deps enriched; analysis tear; proteomic analysis; high myopia ... See more keywords
Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis
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DOI: 10.1186/s12916-025-03855-z
Abstract: Early identification and management of sight-threatening ocular complications of diabetes using imaging or molecular biomarkers could help prevent vision loss. However, access to specialized infrastructure and expertise is limited, especially in remote areas of the… read more here.
Keywords: tear fluid; ocular complications; meta analysis; complications diabetes ... See more keywords
[Features of water-electrolyte component of the tear fluid].
Sign Up to like & getrecommendations! Published in 2023 at "Vestnik oftalmologii"
DOI: 10.17116/oftalma2023139011106
Abstract: Tear production is a complex multi-step process that can be arbitrarily divided into three stages: «primary» secretion by the acinar cells of the main lacrimal glands, formation of «secondary» lacrimal fluid in the ducts of… read more here.
Keywords: electrolyte component; water electrolyte; features water; fluid ... See more keywords
Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis
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DOI: 10.3389/fmed.2022.873483
Abstract: Purpose Tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology… read more here.
Keywords: putative biomarkers; diabetic patients; diabetic retinopathy; biomarkers tears ... See more keywords
Precision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13020386
Abstract: Background: Tear fluid, rich in proteins, is a promising source of novel biomarkers for ocular and systemic health. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the primary method for biomarker discovery. Still, factors such as limited… read more here.
Keywords: small volume; biomarker discovery; individual samples; tear fluid ... See more keywords