Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.09.011
Abstract: The positive transcription elongation factor b (P-TEFb) promotes transcription elongation through phosphorylation of the RNA polymerase II C-terminal domain. This process is not well understood, partly due to difficulties in determining the specificity of P-TEFb… read more here.
Keywords: polymerase terminal; terminal domain; rna polymerase; tefb ... See more keywords
Reconstitution of a functional 7SK snRNP
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx262
Abstract: Abstract The 7SK small nuclear ribonucleoprotein (snRNP) plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. We optimized conditions for analyzing 7SK RNA by SHAPE and demonstrated… read more here.
Keywords: tefb; reconstitution functional; 7sk snrnp; functional 7sk ... See more keywords
SAT-037 Functional Interplay between Distinct P-TEFb Complexes Following Endothelin or α1-Adrenergic Receptor Activation in Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-037
Abstract: Abstract Heart disease is characterized by the remodelling of cardiac tissue following prolonged stress on the heart, such as myocardial infarction and chronic hypertension. The heart initially undergoes hypertrophy of the individual contractile unit, the… read more here.
Keywords: activation; tefb; adrenergic receptor; heart ... See more keywords