Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104118
Abstract: The in vivo proliferation and viability of transfused engineered T cells markedly limits the long-term effect of adoptive cell therapy on tumors. The therapeutic efficacy and proliferative potential of T cells are reported to be… read more here.
Keywords: cell; differentiation specific; specific transcription; differentiation ... See more keywords
P1291 Transcriptional heterogeneity of granzyme K CD8 T Cells in Crohn’s Disease: Implications for tissue inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.1465
Abstract: Crohn’s disease (CD) pathogenesis involves complex interactions between immune cells and intestinal tissues. We investigated the heterogeneity of CD8 effector T cells (Teff) and their role in CD inflammation at the single-cell level. T cells… read more here.
Keywords: teff; cd8; teff cells; gzmk ... See more keywords