Calcium‐binding proteins typify the dopaminergic neuronal subtypes in the ventral tegmental area of zebra finch, Taeniopygia guttata
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25352
Abstract: Calcium‐binding proteins (CBPs) regulate neuronal function in midbrain dopamine (DA)‐ergic neurons in mammals by buffering and sensing the intracellular Ca2+, and vesicular release. In birds, the equivalent set of neurons are important in song learning,… read more here.
Keywords: calbindin calretinin; calcium binding; calretinin; tegmental area ... See more keywords
Calcium rises induced by AMPA and nicotine receptors in the ventral tegmental area show differences in mouse brain slices prenatally exposed to nicotine
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22607
Abstract: Nicotine exposure during gestation is associated with a higher risk of adverse behavioral outcomes including a heightened liability for dependency to drugs of abuse, which can exhibit drug‐specificity influenced by gender. This enhanced liability suggests… read more here.
Keywords: exposed nicotine; tegmental area; ventral tegmental; brain slices ... See more keywords
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1365-7
Abstract: A growing body of evidence suggests that dopamine plays a role in sleep–wake regulation, but the dopamine-producing brain areas that control sleep–wake states are unclear. In this study, we chemogenetically activated dopamine neurons in the… read more here.
Keywords: wakefulness; tegmental area; dopamine; ventral tegmental ... See more keywords
Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0023-3
Abstract: Dopamine (DA) neurons in the ventral tegmental area (VTA) are predicted to play important roles in reward. In pharmacological studies, the rewarding effects of methamphetamine are mediated by DA neurons localized in the VTA. The… read more here.
Keywords: tegmental area; cortex; nac core; ventral tegmental ... See more keywords
Mechanical stimulation of cervical vertebrae modulates the discharge activity of ventral tegmental area neurons and dopamine release in the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2020 at "Brain stimulation"
DOI: 10.1016/j.brs.2019.11.012
Abstract: Background: Growing evidence suggests that mechanical stimulation modulates substrates in the supraspinal central nervous system (CNS) outside the canonical somatosensory circuits. Objective/Methods: We evaluate mechanical stimulation applied to the cervical spine at the C7-T1 level… read more here.
Keywords: tegmental area; stimulation; ventral tegmental; mechanical stimulation ... See more keywords
Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109936
Abstract: Summary Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior.… read more here.
Keywords: chronic neuropathic; depression; tegmental area; ventral tegmental ... See more keywords
An atlas of transcriptionally defined cell populations in the rat ventral tegmental area.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110616
Abstract: The ventral tegmental area (VTA) is a complex brain region that is essential for reward function and frequently implicated in neuropsychiatric disease. While decades of research on VTA function have focused on dopamine neurons, recent… read more here.
Keywords: ventral tegmental; atlas transcriptionally; cell; vta ... See more keywords
Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2017.01.030
Abstract: BACKGROUND The behavioral consequences associated with addiction are thought to arise from drug-induced neuroadaptation. The mesolimbic system plays an important initial role in this process, and while the dopaminergic system specifically has been strongly interrogated,… read more here.
Keywords: area nucleus; tegmental area; ventral tegmental; nucleus accumbens ... See more keywords
Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10360-8
Abstract: The tyrosine kinase, c-Src, participates in mu opioid receptor (MOP) mediated inhibition in sensory neurons in which β-arrestin2 (β-arr2) is implicated in its recruitment. Mice lacking β-arr2 exhibit increased sensitivity to morphine reinforcement; however, whether… read more here.
Keywords: tegmental area; morphine; inhibition; ventral tegmental ... See more keywords
Neural Plasticity in the Ventral Tegmental Area, Aversive Motivation during Drug Withdrawal and Hallucinogenic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of psychoactive drugs"
DOI: 10.1080/02791072.2022.2033889
Abstract: Aberrant glutamatergic signaling has been closely related to several pathologies of the central nervous system. Glutamatergic activity can induce an increase in neural plasticity mediated by brain-derived neurotrophic factor (BDNF) in the ventral tegmental area… read more here.
Keywords: drug; plasticity; neural plasticity; ventral tegmental ... See more keywords
Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Anesthesiology"
DOI: 10.1097/aln.0000000000003347
Abstract: Background: Dexmedetomidine induces a sedative response that is associated with rapid arousal. To elucidate the underlying mechanisms, the authors hypothesized that dexmedetomidine increases the activity of dopaminergic neurons in the ventral tegmental area, and that… read more here.
Keywords: ventral tegmental; dopamine neurons; neurons ventral; dexmedetomidine ... See more keywords