Establishing the structure-activity relationship of teixobactin
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DOI: 10.1016/j.cclet.2019.07.004
Abstract: Abstract In 2015, a new antimicrobial peptide agent was discovered, termed teixobactin. Over the past few years, the structure-activity relationship of teixobactin has been extensively studied. Here, the updated studies have been summarized to provide… read more here.
Keywords: teixobactin; activity; stereochemistry; structure activity ... See more keywords
The Necessity of d-Thr in the New Antibiotic Teixobactin: A Molecular Dynamics Study
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DOI: 10.1021/acs.jcim.8b00949
Abstract: Ever since the discovery of the new antibiotic teixobactin, studies of its structure-activity relationships have never ceased. Here we focus on the chirality of the threonine (Thr) residue, which belongs to the ring motif of… read more here.
Keywords: teixobactin; antibiotic teixobactin; necessity thr; new antibiotic ... See more keywords
Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
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DOI: 10.1021/acs.jmedchem.7b00834
Abstract: Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is… read more here.
Keywords: teixobactin; teixobactin cationic; positive charges; antimicrobial peptide ... See more keywords
Mode of action of teixobactins in cellular membranes
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DOI: 10.1038/s41467-020-16600-2
Abstract: The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The difficult synthesis and unfavourable solubility of teixobactin require modifications, yet insufficient knowledge on its binding mode impedes the hunt for superior analogues. Thus far,… read more here.
Keywords: cellular membranes; teixobactin; teixobactins cellular; cell wall ... See more keywords
Binding Site and Potency Prediction of Teixobactin and other Lipid II Ligands by Statistical Base Scoring of Conformational Space Maps.
Sign Up to like & getrecommendations! Published in 2018 at "Current computer-aided drug design"
DOI: 10.2174/1573409913666170927113813
Abstract: BACKGROUND Lipid II, a peptidoglycan, is a precursor in bacterial cell synthesis. It has both hydrophilic and lipophilic properties. The molecule translocates a bacterial membrane to deliver and incorporate "building blocks" from disaccharide-pentapeptide into the… read more here.
Keywords: teixobactin; potency; lipid ligands; site ... See more keywords
Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2020.00568
Abstract: Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA). A… read more here.
Keywords: enabled chemical; teixobactin; thiol ene; chemical synthesis ... See more keywords