GW29-e0162 Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-γ activation in the coronary artery and VSMCs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.028
Abstract: Telmisartan increases plasma adiponectin levels and improves insulin resistance. Although the mechanisms remained unclear, PRAP activation has been shown to prevent type 2 diabetes. However, it still remains to be investigated the mechanisms whereby telmisartan… read more here.
Keywords: gw29 e0162; telmisartan ameliorates; telmisartan; expression ... See more keywords
Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type‐1 receptor and adiponectin receptor‐1
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.044
Abstract: Aims: The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)‐induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN)… read more here.
Keywords: dimerization; telmisartan; adiponectin receptor; diabetic nephropathy ... See more keywords
Telmisartan Activates PPARδ to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14265-4
Abstract: Major depression is a common mental disorder that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Peroxisome proliferator-activated receptor δ (PPARδ) has been introduced as a… read more here.
Keywords: ppar; depression; telmisartan; stress ... See more keywords
Investigating the attenuating effect of telmisartan against radiation-induced intestinal injury using 18F-FDG micro-PET imaging
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2110295
Abstract: Abstract Background and objective This study was aimed to investigate the ability of 18F-Fluro-deoxy-glucose (18F-FDG)-based micro-positron emission tomography (microPET) imaging to evaluate the efficacy of telmisartan, a highly selective angiotensin II receptor antagonist (ARA), in… read more here.
Keywords: injury; radiation; telmisartan; 18f fdg ... See more keywords
Telmisartan ameliorates LPS‐induced pneumonia in rats through regulation of the PPARγ/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12981
Abstract: Pneumonia is a common disorder of the respiratory system associated with inflammation. Telmisartan (TEL) has been reported to treat inflammatory‐related diseases. The current study aimed to investigate the possible role and action mechanism of telmisartan… read more here.
Keywords: pneumonia rats; induced pneumonia; lps induced; telmisartan ... See more keywords
Telmisartan attenuates human glioblastoma cells proliferation and oncogenicity by inducing the lipid oxidation.
Sign Up to like & getrecommendations! Published in 2021 at "Asia-Pacific journal of clinical oncology"
DOI: 10.1111/ajco.13574
Abstract: BACKGROUND Glioblastoma (GBM) is one of the most common primary brain tumors, which accounts up to 80% of malignant brain tumors and the 5-year relative survival rate is below 5%. Recent studies showed that the… read more here.
Keywords: gbm; telmisartan; proliferation; lipid oxidation ... See more keywords
Telmisartan anti‐cancer activities mechanism through targeting N‐cadherin by mimicking ADH‐1 function
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17259
Abstract: This study aimed to investigate if Telmisartan as a novel N‐cadherin antagonist, can overcome cell migration of cancer cells. We investigated the mechanism and influence of Docetaxel and Telmisartan (as an analogous to ADH‐1, which… read more here.
Keywords: cell; mda 468; cadherin; migration ... See more keywords