Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13324
Abstract: Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging… read more here.
Keywords: telomerase; telomerase activity; genomic epigenomic; pan cancer ... See more keywords
Nanogap‐Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201701832
Abstract: Telomerase has attracted much attention as a universal cancer biomarker because telomerase is overexpressed in more than 85% of human cancer cells while suppressed in normal somatic cells. Since a strong association exists between telomerase… read more here.
Keywords: telomerase; rich nanowire; nanogap rich; telomerase activity ... See more keywords
DNA‐Based Nanoprobes for Simultaneous Detection of Telomerase and Correlated Biomolecules
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200307
Abstract: Telomerase (TE), a ribonucleoprotein reverse transcriptase, is enzymatically activated in most tumor cells and is responsible for promoting tumor progression and malignancy by enabling replicative immortality of cancer cells. TE has become an important hallmark… read more here.
Keywords: telomerase; based nanoprobes; detection; dna based ... See more keywords
Maternal testosterone affects offspring telomerase activity in a long‐lived seabird
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.9281
Abstract: Abstract Androgens are a group of steroid hormones that have long been proposed as a mechanism underpinning intergenerational plasticity. In birds, maternally allocated egg testosterone, one of the main androgens in vertebrates, affects a wide… read more here.
Keywords: telomerase; testosterone affects; activity; maternal testosterone ... See more keywords
Overexpression of the telomerase holoenzyme induces EMT and tumorigenesis of HPV‐immortalized keratinocytes
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28681
Abstract: Cervical cancer is the most frequent malignancy of the female genital tract and is associated with persistent infection of the uterine cervix with high‐risk human papillomaviruses (HPV). The two HPV oncoproteins, E6 and E7, cooperatively… read more here.
Keywords: overexpression telomerase; telomerase; immortalized keratinocytes; hpv ... See more keywords
Single-Run Catalysis and Kinetic Control of Human Telomerase Holoenzyme.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_676
Abstract: Genome stability in eukaryotic cells relies on proper maintenance of telomeres at the termini of linear chromosomes. Human telomerase holoenzyme is required for maintaining telomere stability in a majority of proliferative human cells, making it… read more here.
Keywords: telomerase holoenzyme; control human; human telomerase; telomerase ... See more keywords
ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7778-9_29
Abstract: Telomerase is a cellular RNA template-dependent reverse transcriptase that adds telomere repeats to the 3' ends of chromosomes. Telomerase is expressed almost universally in tumor cells (>85%) to maintain telomere length, thus providing the ability… read more here.
Keywords: precise quantification; telomerase; sensitive precise; ddtrap ... See more keywords
Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-55035-6_10
Abstract: Telomerases are attractive targets for development of new anticancer agents. Most tumors express the enzyme telomerase that maintains telomere length and thus ensures indefinite cell proliferation, a hallmark of cancer. Curcumin has been shown to… read more here.
Keywords: telomerase target; target therapeutic; telomerase; effects curcumin ... See more keywords
Interventions Addressing the Telomere-Telomerase System.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9721-0_26
Abstract: Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder,… read more here.
Keywords: telomere telomerase; telomerase; psychiatric illnesses; telomerase system ... See more keywords
Magnetic bead-enzyme assemble for triple-parameter telomerase detection at single-cell level
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02741-2
Abstract: In this work, we developed a triple-parameter strategy for the detection of telomerase activity from cancer cells and urine samples. This strategy was developed based on magnetic bead-enzyme hybrids combined with fluorescence analysis, colorimetric assay,… read more here.
Keywords: telomerase; bead enzyme; detection; magnetic bead ... See more keywords
Shortening of the leucocytes’ telomeres length in T2DM independent of age and telomerase activity
Sign Up to like & getrecommendations! Published in 2020 at "Acta Diabetologica"
DOI: 10.1007/s00592-020-01550-4
Abstract: Aims This study aimed to examine the role of plasma telomerase (TE), plasma insulin, patient’s age and disease duration in determination of the leucocytes’ telomeres length (LTL) in T2DM. Methods Blood samples from Kuwaiti patients… read more here.
Keywords: independent age; telomerase; age; telomeres length ... See more keywords