Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13324
Abstract: Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging… read more here.
Keywords: telomerase; telomerase activity; genomic epigenomic; pan cancer ... See more keywords
Nanogap‐Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201701832
Abstract: Telomerase has attracted much attention as a universal cancer biomarker because telomerase is overexpressed in more than 85% of human cancer cells while suppressed in normal somatic cells. Since a strong association exists between telomerase… read more here.
Keywords: telomerase; rich nanowire; nanogap rich; telomerase activity ... See more keywords
Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas – a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgical Review"
DOI: 10.1007/s10143-019-01087-3
Abstract: Telomerase activity and (human) Telomerase Reverse Transcriptase (hTERT) expression are considered hallmarks in oncogenesis of neoplasms and are upregulated by alterations of the hTERT promoter. In meningiomas, numerous studies investigated hTERT expression, telomerase activity, promoter… read more here.
Keywords: telomerase; telomerase activity; expression; htert ... See more keywords
Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-018-0138-6
Abstract: Background:Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is… read more here.
Keywords: telomerase activity; efficacy; pluripotency; differentiation ... See more keywords
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101411
Abstract: Telomeres protect genomic stability and shortening is one of the hallmarks of ageing. Telomerase reverse transcriptase (TERT) is the major protein component of telomerase, which elongates telomeres. Given that short telomeres are linked to a… read more here.
Keywords: telomerase activity; telomerase; activity; exercise training ... See more keywords
Rhodospirillum rubruml-asparaginase targets tumor growth by a dual mechanism involving telomerase inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.078
Abstract: Rhodospirillum rubruml-asparaginase mutant RrA E149R, V150P, F151T (RrA) was previously identified to down-regulate telomerase activity along with catalyzing the hydrolysis of l-asparagine. The aim of this study was to define the effect of prolonged RrA… read more here.
Keywords: rra; telomerase; telomerase activity; inhibition ... See more keywords
Regulation of cell fate by near infrared-responsive telomerase activity
Sign Up to like & getrecommendations! Published in 2017 at "Materials Today"
DOI: 10.1016/j.mattod.2017.07.004
Abstract: As a key regulator, telomerase plays important roles in aging and tissue renewal and lifespan. It has been demonstrated that telomerase reactivation in adult or old mice can lead to tissue regeneration, delayed aging and… read more here.
Keywords: telomerase; telomerase activity; near infrared; cell ... See more keywords
PCR-free paper-based nanobiosensing platform for visual detection of telomerase activity via gold enhancement
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.104594
Abstract: Abstract Telomerase activity has been demonstrated in a wide variety of most solid tumors and considered as a well-known cancer biomarker. The commonly utilized method for its detection is polymerase chain reaction (PCR)-based telomeric repeat… read more here.
Keywords: telomerase; detection; telomerase activity; paper ... See more keywords
Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112318
Abstract: Epidermal growth factor (EGF)-receptor regulates several downstream signaling pathways upon EGF stimulation that involves cell proliferation, migration and invasion. Internalized EGF-receptor is either recycled or degraded, which fate is regulated in part by Ras interference… read more here.
Keywords: expression rin1; 231 cells; rin1; mda 231 ... See more keywords
Point-of-Care Assay of Telomerase Activity at Single-Cell Level via Gas Pressure Readout.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01529
Abstract: Detection of telomerase activity at the single-cell level is one of the central challenges in cancer diagnostics and therapy. Herein, we describe a facile and reliable point-of-care testing (POCT) strategy for detection of telomerase activity… read more here.
Keywords: telomerase; telomerase activity; gas; cell ... See more keywords
In Situ Detection and Imaging of Telomerase Activity in Cancer Cell Lines via Disassembly of Plasmonic Core-Satellites Nanostructured Probe.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01882
Abstract: The label-free localized surface plasmon resonance (LSPR) detection technique has been identified as a powerful means for in situ investigation of biological processes and localized chemical reactions at single particle level with high spatial and… read more here.
Keywords: au13; telomerase; detection; telomerase activity ... See more keywords