Hydrosoluble Perylene Monoimide-Based Telomerase Inhibitors with Diminished Cytotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01343
Abstract: Telomerase is essential for the immortality characteristics of most cancers. Telomerase-specific inhibitors should render cancer cells to replicative senescence without acute cytotoxicity. Perylene-based G-quadruplex (G4) ligands are widely studied as telomerase inhibitors. Most reported perylene-based… read more here.
Keywords: telomerase; cytotoxicity; perylene monoimide; telomerase inhibitors ... See more keywords
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
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DOI: 10.1038/s41467-020-19115-y
Abstract: Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two distinct mechanisms by which naturally occurring oxidized… read more here.
Keywords: mechanisms telomerase; telomerase; telomerase inhibition; therapeutic dntps ... See more keywords
Telomerase inhibition is an effective therapeutic strategy in TERT promoter mutant-glioblastoma models with low tumor volume.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noad024
Abstract: BACKGROUND Glioblastoma is among the deadliest of all cancers, with 5-year survival rates of only 6%. Glioblastoma targeted therapeutics have been challenging to develop due to significant inter- and intra-tumoral heterogeneity. TERT promoter mutations are… read more here.
Keywords: glioblastoma; low tumor; tert promoter; telomerase inhibition ... See more keywords