Articles with "telomerase inhibitors" as a keyword



Hydrosoluble Perylene Monoimide-Based Telomerase Inhibitors with Diminished Cytotoxicity

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Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01343

Abstract: Telomerase is essential for the immortality characteristics of most cancers. Telomerase-specific inhibitors should render cancer cells to replicative senescence without acute cytotoxicity. Perylene-based G-quadruplex (G4) ligands are widely studied as telomerase inhibitors. Most reported perylene-based… read more here.

Keywords: telomerase; cytotoxicity; perylene monoimide; telomerase inhibitors ... See more keywords
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Telomerase Inhibitors from Natural Products and Their Anticancer Potential

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Published in 2017 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms19010013

Abstract: Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy. Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in almost all cancer cells, which is mainly responsible to regulate… read more here.

Keywords: telomerase; natural products; telomerase inhibitors; inhibitors natural ... See more keywords