A radiomics‐based nomogram may be useful for predicting telomerase reverse transcriptase promoter mutation status in adult glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3528
Abstract: As a crucial diagnostic and prognostic biomarker, telomerase reverse transcriptase (TERT) promoter mutation holds immense significance for personalized treatment of patients with glioblastoma (GBM). In this study, we developed a radiomics nomogram to determine the… read more here.
Keywords: telomerase reverse; promoter; mutation status; reverse transcriptase ... See more keywords
Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07204-w
Abstract: Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance. In addition to its telomere… read more here.
Keywords: telomerase reverse; apoptosis; treatment; cisplatin ... See more keywords
Telomerase reverse transcriptase (TERT) promoter mutation correlated with intratumoral heterogeneity in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Pathology International"
DOI: 10.1111/pin.12974
Abstract: Telomerase reverse transcriptase (TERT) promoter mutations are frequently observed in hepatocellular carcinoma (HCC); however, the impact of TERT promoter mutations (TPMs) on clinical features and morphological patterns in HCC remains unresolved. Using DNA extracted from… read more here.
Keywords: telomerase reverse; heterogeneity; tert promoter; promoter ... See more keywords
The Regulation of ROS- and BECN1-Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/6636510
Abstract: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with high morbidity and mortality. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, is overexpressed in most cancers including GBM. It… read more here.
Keywords: telomerase; telomerase reverse; glioblastoma; human telomerase ... See more keywords
Abstract 4199: Defining roles of telomerase reverse transcriptase in DNA damage response
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4199
Abstract: Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase, is essential for telomere maintenance, elongating the G-strand of telomeric DNA using its associated RNA template (TR). Recruitment of TERT to telomeres is mediated by the… read more here.
Keywords: dna damage; cancer; telomerase reverse; tert ... See more keywords
Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.116.308717
Abstract: Objective— Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling during atherosclerosis and neointima formation. Telomerase is rate limiting for tissue renewal and cell replication; however, the physiological role… read more here.
Keywords: silencing e2f1; telomerase reverse; formation; tert ... See more keywords
Pleuroparenchymal fibroelastosis associated with telomerase reverse transcriptase mutations
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.02022-2016
Abstract: We read with great interest the article by Newton et al. [1]. They found that mutations in the telomere maintenance machinery genes (telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), regulator of telomere elongation helicase… read more here.
Keywords: reverse transcriptase; telomerase reverse; fibroelastosis associated; pleuroparenchymal fibroelastosis ... See more keywords
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes
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DOI: 10.1371/journal.pone.0166853
Abstract: Introduction Telomerase repairs the telomeric ends of chromosomes and is active in nearly all malignant cells. Hepatitis C virus (HCV) is known to be oncogenic and potential interactions with the telomerase system require further study.… read more here.
Keywords: telomerase; telomerase reverse; telomerase activity; human hepatocytes ... See more keywords
Impaired Hippocampal Synaptic Plasticity and Enhanced Excitatory Transmission in a Novel Animal Model of Autism Spectrum Disorders with Telomerase Reverse Transcriptase Overexpression
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.0145
Abstract: Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors symptoms that mirror those observed in human autism spectrum… read more here.
Keywords: tert overexpression; overexpression; telomerase reverse; tert ... See more keywords
A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms
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DOI: 10.3389/ebm.2024.10021
Abstract: The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) peptides with… read more here.
Keywords: phase trial; telomerase reverse; transcriptase htert; vaccination ... See more keywords
Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase
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DOI: 10.3390/bioengineering12040335
Abstract: A fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT). hTERT is reactivated during carcinogenesis and is overexpressed in more than 90% of cancers but… read more here.
Keywords: reporter; cell based; telomerase reverse; reverse transcriptase ... See more keywords