Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07204-w
Abstract: Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance. In addition to its telomere… read more here.
Keywords: telomerase reverse; apoptosis; treatment; cisplatin ... See more keywords
Telomerase reverse transcriptase (TERT) promoter mutation correlated with intratumoral heterogeneity in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Pathology International"
DOI: 10.1111/pin.12974
Abstract: Telomerase reverse transcriptase (TERT) promoter mutations are frequently observed in hepatocellular carcinoma (HCC); however, the impact of TERT promoter mutations (TPMs) on clinical features and morphological patterns in HCC remains unresolved. Using DNA extracted from… read more here.
Keywords: telomerase reverse; heterogeneity; tert promoter; promoter ... See more keywords
The Regulation of ROS- and BECN1-Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/6636510
Abstract: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with high morbidity and mortality. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, is overexpressed in most cancers including GBM. It… read more here.
Keywords: telomerase; telomerase reverse; glioblastoma; human telomerase ... See more keywords
Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.116.308717
Abstract: Objective— Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling during atherosclerosis and neointima formation. Telomerase is rate limiting for tissue renewal and cell replication; however, the physiological role… read more here.
Keywords: silencing e2f1; telomerase reverse; formation; tert ... See more keywords
Pleuroparenchymal fibroelastosis associated with telomerase reverse transcriptase mutations
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.02022-2016
Abstract: We read with great interest the article by Newton et al. [1]. They found that mutations in the telomere maintenance machinery genes (telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), regulator of telomere elongation helicase… read more here.
Keywords: reverse transcriptase; telomerase reverse; fibroelastosis associated; pleuroparenchymal fibroelastosis ... See more keywords
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0166853
Abstract: Introduction Telomerase repairs the telomeric ends of chromosomes and is active in nearly all malignant cells. Hepatitis C virus (HCV) is known to be oncogenic and potential interactions with the telomerase system require further study.… read more here.
Keywords: telomerase; telomerase reverse; telomerase activity; human hepatocytes ... See more keywords
Impaired Hippocampal Synaptic Plasticity and Enhanced Excitatory Transmission in a Novel Animal Model of Autism Spectrum Disorders with Telomerase Reverse Transcriptase Overexpression
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.0145
Abstract: Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors symptoms that mirror those observed in human autism spectrum… read more here.
Keywords: tert overexpression; overexpression; telomerase reverse; tert ... See more keywords
Deciphering the Functions of Telomerase Reverse Transcriptase in Head and Neck Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030691
Abstract: Head and neck cancers (HNCs) are among the ten leading malignancies worldwide. Despite significant progress in all therapeutic modalities, predictive biomarkers, and targeted therapies for HNCs are limited and the survival rate is unsatisfactory. The… read more here.
Keywords: promoter; reverse transcriptase; head neck; telomerase reverse ... See more keywords
Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12081188
Abstract: The proliferative capacity and continuous survival of cells are highly dependent on telomerase expression and the maintenance of telomere length. For this reason, elevated expression of telomerase has been identified in virtually all cancers, including… read more here.
Keywords: htert regulation; reverse transcriptase; telomerase; telomerase reverse ... See more keywords
An Identification and Characterization of the Axolotl (Ambystoma mexicanum, Amex) Telomerase Reverse Transcriptase (Amex TERT)
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13020373
Abstract: The Mexican axolotl is one of the few vertebrates that is able to replace its lost body parts during lifespan. Due to its remarkable regenerative abilities, the axolotl emerged as a model organism especially for… read more here.
Keywords: reverse transcriptase; telomerase reverse; axolotl; telomerase ... See more keywords
Functional Interactions of Kluyveromyces lactis Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810757
Abstract: The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus… read more here.
Keywords: telomerase; structure; reverse transcriptase; telomerase rna ... See more keywords