Life and Death of Yeast Telomerase RNA.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.01.013
Abstract: Telomerase reverse transcriptase elongates telomeres to overcome their natural attrition and allow unlimited cellular proliferation, a characteristic shared by stem cells and the majority of malignant cancerous cells. The telomerase holoenzyme comprises a core RNA… read more here.
Keywords: telomerase; death yeast; telomerase rna; life death ... See more keywords
Live-cell imaging of budding yeast telomerase RNA and TERRA.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.07.014
Abstract: In most eukaryotes, the ribonucleoprotein complex telomerase is responsible for maintaining telomere length. In recent years, single-cell microscopy techniques such as fluorescent in situ hybridization and live-cell imaging have been developed to image the RNA… read more here.
Keywords: cell imaging; live cell; telomerase rna; rna terra ... See more keywords
Sticky-flares for in situ monitoring of human telomerase RNA in living cells.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c8nr01260a
Abstract: Human telomerase RNA (hTR), a template of telomerase for telomeric repeat synthesis, was used to reflect the telomerase activity and act as a potential target of antitumor therapy. Here, we report a novel DNA-conjugated AuNP… read more here.
Keywords: telomerase; telomerase rna; sticky flares; living cells ... See more keywords
Biogenesis of telomerase RNA from a protein-coding mRNA precursor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204636119
Abstract: Significance Many noncoding RNA molecules are indispensable components of macromolecular complexes that govern critical cellular processes. Telomerase RNA is a long noncoding RNA essential for maintaining chromosome stability and cellular immortality in eukaryotes. In this… read more here.
Keywords: coding mrna; telomerase rna; rna; protein coding ... See more keywords
In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1042
Abstract: Abstract Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR,… read more here.
Keywords: vivo; telomerase; brucei; telomerase rna ... See more keywords
Telomerase RNA plays a major role in the completion of the life cycle in Ustilago maydis and shares conserved domains with other Ustilaginales
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281251
Abstract: The RNA subunit of telomerase is an essential component whose primary sequence and length are poorly conserved among eukaryotic organisms. The phytopathogen Ustilago maydis is a dimorphic fungus of the order Ustilaginales. We analyzed several… read more here.
Keywords: telomerase; cycle; ustilago maydis; rna plays ... See more keywords
Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061275
Abstract: Telomerase RNA has long been considered to be a noncoding component of telomerase. However, the expression of the telomerase RNA gene is not always associated with telomerase activity. The existence of distinct TERC gene expression… read more here.
Keywords: telomerase; processing transport; telomerase rna; rna ... See more keywords
Functional Interactions of Kluyveromyces lactis Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810757
Abstract: The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus… read more here.
Keywords: telomerase; structure; reverse transcriptase; telomerase rna ... See more keywords
The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.40037
Abstract: Telomerase RNA (TR) provides the template for DNA repeat synthesis at telomeres and is essential for genome stability in continuously dividing cells. We mapped the RNA interactome of human TR (hTR) and identified a set… read more here.
Keywords: rna interactome; telomerase rna; histone mrna; rna ... See more keywords