O019 Studying telomere biology and genomic instability in gliomas
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Surgery"
DOI: 10.1093/bjs/znad101.019
Abstract: Glioblastoma (GBM) is the most aggressive primary brain cancer. Identifying novel markers which stratify patients and predict response to targeted therapies is a priority. Telomeres are caps on chromosome ends protecting them from aberrant DNA… read more here.
Keywords: genomic instability; studying telomere; telomere biology; o019 studying ... See more keywords
Integrating telomere biology into the ecology and evolution of natural populations: Progress and prospects
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DOI: 10.1111/mec.16768
Abstract: Telomeres are fascinating stretches of protective DNA that cap the chromosome ends of eukaryotes. Without telomeres, during cell division and DNA replication, DNA repair proteins would misread the ends of chromosomes and attempt to repair… read more here.
Keywords: ecology; natural populations; telomere biology; ecology evolution ... See more keywords
Functional interaction between compound heterozygous TERT mutations causes severe telomere biology disorder
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DOI: 10.1182/bloodadvances.2022007029
Abstract: Key Points A patient with a severe form of telomere biology disorder has compound heterozygous variants in TERT that interact functionally. The functional interaction between alleles explains the much more extreme phenotype in the proband… read more here.
Keywords: biology disorder; compound heterozygous; telomere biology; functional interaction ... See more keywords
Telomere biology: from disorders to hematological diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1167848
Abstract: Variations in the length of telomeres and pathogenic variants involved in telomere length maintenance have been correlated with several human diseases. Recent breakthroughs in telomere biology knowledge have contributed to the identification of illnesses named… read more here.
Keywords: disorders hematological; telomere biology; physiology; hematological diseases ... See more keywords