Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1910574116
Abstract: Significance It is highly controversial whether secondary reactive oxygen species generated by dysfunctional mitochondria are able to diffuse across the cytoplasm to the nucleus and cause subsequent nuclear changes. We have developed a targeted chemoptogenetic… read more here.
Keywords: oxygen; dysfunction; mitochondria; damage ... See more keywords
Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13875
Abstract: In advanced age, increases in oxidative stress and inflammation impair endothelial function, which contributes to the development of cardiovascular disease (CVD). One plausible source of this oxidative stress and inflammation is an increase in the… read more here.
Keywords: cell; cell telomere; telomere dysfunction; senescence ... See more keywords
The role of senescence, telomere dysfunction and shelterin in vascular aging
Sign Up to like & getrecommendations! Published in 2019 at "Microcirculation"
DOI: 10.1111/micc.12487
Abstract: In the United States and other westernized nations, CVDs are the leading cause of death in adults over 65 years of age. Large artery stiffness and endothelial dysfunction are increased with age and age‐associated arterial… read more here.
Keywords: age; dysfunction; shelterin vascular; vascular aging ... See more keywords
Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2019-0374oc
Abstract: RATIONALE Telomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD)-the major limitation to long-term survival following lung transplantation. Although shorter donor telomere lengths are associated with an increased risk… read more here.
Keywords: lung; dysfunction; chronic lung; epithelial cells ... See more keywords
Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008368
Abstract: Telomere shortening is associated with aging and age-associated diseases. Additionally, telomere dysfunction resulting from telomerase gene mutation can lead to premature aging, such as apparent skin atrophy and hair loss. However, the molecular signaling linking… read more here.
Keywords: dysfunction; psmad p63; differentiation; bmp psmad ... See more keywords
Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.28020
Abstract: Telomerase/telomere-targeting therapy is a potentially promising approach for cancer treatment because even transient telomere dysfunction can induce chromosomal instability (CIN) and may be a barrier to tumor growth. We recently developed a dual-HAC (Human Artificial… read more here.
Keywords: hac; platinum; compounds induce; cancer ... See more keywords
Lung Transplant Improves Survival and Quality of Life Regardless of Telomere Dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.695919
Abstract: Introduction: Fibrotic interstitial lung diseases (ILDs) are the first indication for lung transplantation (LT). Telomere dysfunction has been associated with poor post-transplant outcomes. The aim of the study was to evaluate the morbi-mortality and quality… read more here.
Keywords: lung transplant; quality life; telomere dysfunction;
Telomere Dysfunction in Chronic Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.612665
Abstract: Telomeres are nucleprotein structures that cap the chromosomal ends, conferring genomic stability. Alterations in telomere maintenance and function are associated with tumorigenesis. In chronic lymphocytic leukemia (CLL), telomere length is an independent prognostic factor and… read more here.
Keywords: cll; lymphocytic leukemia; dysfunction; chronic lymphocytic ... See more keywords
A Central Role of Telomere Dysfunction in the Formation of a Unique Translocation within the Sub-Telomere Region Resulting in Duplication and Partial Trisomy
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101762
Abstract: Telomeres play a major role in maintaining genome stability and integrity. Putative involvement of telomere dysfunction in the formation of various types of chromosomal aberrations is an area of active research. Here, we report a… read more here.
Keywords: role; region; telomere dysfunction; formation ... See more keywords