PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.
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DOI: 10.1016/j.lfs.2021.119556
Abstract: OBJECTIVE Poly(ADP-ribose) polymerase-1 (PARP1) interacts and poly(ADP-ribosyl)ates telomere repeat binding factor 2 (TRF2), which acts as a platform to recruit a large number of proteins at the telomere. Since the discovery of TRF2-SLX4 interaction, SLX4… read more here.
Keywords: telomere localization; slx4; telomere length; u2os cells ... See more keywords