Long telomeres at baseline and male sex are main determinants of telomere loss following chemotherapy exposure in lymphoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "Hematological oncology"
DOI: 10.1002/hon.3118
Abstract: Although chemotherapy (CHT) exposure is an established cause of telomere attrition, determinants of telomere length (TL) dynamics after chemotherapy are poorly defined. In this study, we analyzed granulocyte telomere dynamics in 34 adult lymphoma patients… read more here.
Keywords: exposure; telomere loss; cht; chemotherapy ... See more keywords
Telomere aberrations, including telomere loss, doublets, and extreme shortening, are increased in patients with infertility.
Sign Up to like & getrecommendations! Published in 2020 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.07.005
Abstract: OBJECTIVE To test the hypothesis that telomere shortening and/or loss are risk factors for infertility. DESIGN Retrospective analysis of the telomere status in patients with infertility using conventional cytogenetic data collected prospectively. SETTING Academic centers.… read more here.
Keywords: patients infertility; telomere loss; telomere aberrations; cytogenetic slides ... See more keywords
Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95326-7
Abstract: Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, like knee OA. In a dynamic… read more here.
Keywords: blood leukocytes; telomere loss; osteoarthritis; peripheral blood ... See more keywords
RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
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DOI: 10.1093/nar/gkx1322
Abstract: Abstract Replicative erosion of telomeres is naturally compensated by telomerase and studies in yeast and vertebrates show that homologous recombination can compensate for the absence of telomerase. We show that RAD51 protein, which catalyzes the… read more here.
Keywords: telomerase; telomere loss; homologous recombination; absence telomerase ... See more keywords
Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0446
Abstract: Much telomere loss takes place during the period of most rapid growth when cell proliferation and potentially energy expenditure are high. Fast growth is linked to reduced longevity. Therefore, the effects of somatic cell proliferation… read more here.
Keywords: somatic growth; growth telomere; telomere loss; dynamics vertebrates ... See more keywords