Loss of Chromosome Y in Neuroblastoma Is Associated With High‐Risk Disease, 11q‐Deletion, and Telomere Maintenance
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DOI: 10.1002/gcc.23260
Abstract: Neuroblastoma (NB) is a heterogeneous childhood cancer with a slightly higher incidence in boys than girls, with the reason for this gender disparity unknown. Given the growing evidence for the involvement of loss of the… read more here.
Keywords: loss chromosome; 11q deletion; telomere maintenance; high risk ... See more keywords
Telomere maintenance during anterior regeneration and aging in the freshwater annelid Aeolosoma viride
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DOI: 10.1038/s41598-018-36396-y
Abstract: Aging is a complex process involving declines in various cellular and physical functionalities, including regenerative ability. Telomere maintenance is thought to be necessary for regeneration, and telomere attrition is one mechanism that contributes to aging.… read more here.
Keywords: aeolosoma viride; telomere maintenance; regeneration; freshwater annelid ... See more keywords
Set1 regulates telomere function via H3K4 methylation–dependent and -independent pathways and calibrates the abundance of telomere maintenance factors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-06-0213
Abstract: Set1 is an H3K4 methyltransferase which comprises the catalytic subunit of the COMPASS complex and has been implicated in transcription, DNA repair, cell cycle control, and numerous other genomic functions. Set1 also promotes proper telomere… read more here.
Keywords: set1; methylation dependent; h3k4 methylation; telomere maintenance ... See more keywords
RBIO-10. Targeting telomere maintenance sensitizes group 3 medulloblastomas to ionizing radiation
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DOI: 10.1093/neuonc/noaf201.1550
Abstract: Ionizing radiation (IR) is part of standard care for group 3 (G3) medulloblastomas (MBs), the most aggressive molecular subtype of the most common malignant pediatric brain cancer. However, IR is often not curative and causes… read more here.
Keywords: zscan4; maintenance; ionizing radiation; telomere maintenance ... See more keywords
Genetic variants in telomere‐maintenance genes are associated with ovarian cancer risk and outcome
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DOI: 10.1111/jcmm.12995
Abstract: Most ovarian cancer patients present at an advanced stage with poor prognosis. Telomeres play a critical role in protecting chromosomes stability. The associations of genetic variants in telomere maintenance genes and ovarian cancer risk and… read more here.
Keywords: cancer risk; telomere maintenance; ovarian cancer; maintenance genes ... See more keywords
A systematic look at a childhood tumor
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DOI: 10.1126/science.362.6419.1124-a
Abstract: Cancer Neuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well to treatment and some undergo spontaneous… read more here.
Keywords: look childhood; risk tumors; maintenance mechanisms; telomere maintenance ... See more keywords
A mechanistic classification of clinical phenotypes in neuroblastoma
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DOI: 10.1126/science.aat6768
Abstract: A systematic look at a childhood tumor Neuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well… read more here.
Keywords: mechanistic classification; telomere maintenance; maintenance mechanisms; tumor ... See more keywords
Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma
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DOI: 10.1158/0008-5472.can-19-3068
Abstract: These findings assess telomere maintenance mechanisms with TERT mRNA and the ALT DNA biomarker C-circles to stratify neuroblastoma into three groups, with distinct overall survival independent of currently used clinical risk classifiers. Neuroblastoma is a… read more here.
Keywords: high risk; alt; tert; risk neuroblastoma ... See more keywords
Abstract 4881: Dissecting telomere maintenance mechanisms in neuroblastoma
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DOI: 10.1158/1538-7445.am2017-4881
Abstract: Background. Telomere maintenance is a major cancer hallmark and has recently attracted attention as an oncogenic mechanism in the pediatric malignancy, neuroblastoma (NBL), due to detection of frequent structural rearrangements near the telomerase (TERT) gene.… read more here.
Keywords: methylation; maintenance; high risk; maintenance mechanisms ... See more keywords
Abstract 5821: The role ofSMARCAL1loss-of-function mutations in glioblastoma telomere maintenance
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5821
Abstract: Malignant tumor cells overcome the restriction of progressive telomere shortening by employing telomere maintenance mechanisms (TMMs) to achieve replicative immortality. Over 80% of human cancers maintain telomere length using the enzyme telomerase, which uses an… read more here.
Keywords: function mutations; mutations glioblastoma; telomere maintenance; function ... See more keywords
TelNet - a database for human and yeast genes involved in telomere maintenance
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genetics"
DOI: 10.1186/s12863-018-0617-8
Abstract: BackgroundThe ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere… read more here.
Keywords: telnet database; telomere maintenance; yeast genes;