Rare Protein-altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.201902-0360oc
Abstract: RATIONALE Rare genetic variants in telomere-related genes have been identified in familial, idiopathic, and rheumatoid arthritis-associated pulmonary fibrosis. Short peripheral blood leukocyte (PBL) telomere length predicts poor outcomes in chronic hypersensitivity pneumonitis (CHP). OBJECTIVES Determine… read more here.
Keywords: telomere length; chronic hypersensitivity; rare protein; telomere related ... See more keywords
Telomere-related Markers for Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Current Topics in Medicinal Chemistry"
DOI: 10.2174/1568026620666200106145340
Abstract: Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which serves as an important barrier… read more here.
Keywords: telomere related; related markers; maintenance; cancer telomere ... See more keywords
Telomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.975057
Abstract: Kidney cancer is one of the most common urological cancers worldwide, and kidney renal clear cell cancer (KIRC) is the major histologic subtype. Our previous study found that von-Hippel Lindau (VHL) gene mutation, the dominant… read more here.
Keywords: telomere related; kidney cancer; risk; cohort ... See more keywords
Telomere-related genes as potential biomarkers to predict endometriosis and immune response: Development of a machine learning-based risk model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1132676
Abstract: Introduction Endometriosis (EM) is an aggressive, pleomorphic, and common gynecological disease. Its clinical presentation includes abnormal menstruation, dysmenorrhea, and infertility, which seriously affect the patient's quality of life. However, the pathogenesis underlying EM and associated… read more here.
Keywords: endometriosis; development; machine learning; telomere related ... See more keywords
Epigenetic Deregulation of Telomere-Related Genes in Newly Diagnosed Multiple Myeloma Patients
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DOI: 10.3390/cancers13246348
Abstract: Simple Summary Aberrant expression of telomere-related genes (TRGs) and telomere-shortening facilitates development of different types of cancer. Given the fact that high-risk multiple myeloma (MM) patients harbor critically shortened telomeres, we investigated the epigenetic basis… read more here.
Keywords: telomere related; expression; myeloma patients; methylation ... See more keywords