Tomentosin Induces Telomere Shortening and Caspase‐Dependant Apoptosis in Cervical Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25826
Abstract: Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti‐proliferative, telomere shortening, and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit… read more here.
Keywords: caspase; telomere shortening; apoptosis; cervical cancer ... See more keywords
Urothelial cell senescence is not linked with telomere shortening
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2900
Abstract: The success of regenerative medicine relies in part on the quality of the cells implanted. Cell cultures from cells isolated from bladder washes have been successfully established, but molecular changes and cell characteristics have not… read more here.
Keywords: medicine; telomere shortening; senescence; bladder washes ... See more keywords
Severe telomere shortening in Fanconi anemia complementation group L.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06101-2
Abstract: Fanconi Anemia (FA) is a rare genetic disease with the incidence of 1 in 360,000 and is characterised by bone marrow failure, physical abnormalities, pancytopenia, and high frequency of chromosomal breakage and increased risk of… read more here.
Keywords: telomere shortening; fanconi anemia; telomere length; severe telomere ... See more keywords
Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in cardiovascular diseases"
DOI: 10.1016/j.pcad.2020.05.009
Abstract: AIMS Current evidence points to cellular anti-ageing effects of regular endurance training which may differ from other sport modalities. Effects of football training on markers of cell senescence have not been tested. METHODS One hundred… read more here.
Keywords: telomere shortening; football; telomere length; football players ... See more keywords
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.04.018
Abstract: Summary Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected proliferation-independent telomere shortening in… read more here.
Keywords: dmd; telomere shortening; tissue stiffness; stiffness triggers ... See more keywords
Telomere shortening associates with elevated insulin and nuchal fat accumulation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63916-6
Abstract: Obesity and relative leucocyte telomere length (RTL) are both linked to accelerated aging and premature mortality. We examined if nuchal subcutaneous adipose tissue (SAT) thickness, a surrogate marker of central trunk-weighted obesity, is an independent… read more here.
Keywords: insulin; telomere shortening; sat thickness; nuchal sat ... See more keywords
Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dietary supplements"
DOI: 10.1080/19390211.2020.1854919
Abstract: Shortened telomeres are associated with aging and age-related diseases. Oxidative stress is thought to be a major contributor to telomere shortening, and antioxidants may be able to mitigate these effects. Ergothioneine is a naturally occurring… read more here.
Keywords: ergothioneine; telomere shortening; stress conditions; telomere length ... See more keywords
Reduced telomere length in amniocytes: an early biomarker of abnormal fetal development?
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac054
Abstract: Telomeres protect chromosome ends and control cell division and senescence. During organogenesis, telomeres need to be long enough to ensure the cell proliferation necessary at this stage of development. Previous studies have shown that telomere… read more here.
Keywords: amniocytes early; telomere shortening; telomere length; development ... See more keywords
Telomere shortening impairs alveolar regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13211
Abstract: Short telomeres in alveolar type 2 (AT2) cells have been associated with many lung diseases. The study aimed to investigate the regeneration capacity of AT2 cells with short telomeres by knocking out Tert in mice… read more here.
Keywords: regeneration; telomere shortening; shortening impairs; impairs alveolar ... See more keywords
Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.18935
Abstract: Background: Heart failure (HF) coincides with cardiomyocyte telomere shortening. Arterial hypertension is the most prominent risk factor for HF. Both HF and arterial hypertension are associated with dysregulation of the neurohormonal axis. How neurohormonal activation… read more here.
Keywords: dna damage; telomere shortening; heart failure; heart ... See more keywords
Erratum to: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Research"
DOI: 10.1186/s12931-017-0589-7
Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere… read more here.
Keywords: patients copd; telomere shortening; accelerated aging; telomere length ... See more keywords