Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
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DOI: 10.1038/s41467-020-20711-1
Abstract: Telomeres are organized into a heterochromatin structure and maintenance of silent heterochromatin is required for chromosome stability. How telomere heterochromatin is dynamically regulated in response to stimuli remains unknown. Pyruvate kinase Pyk1 forms a complex… read more here.
Keywords: heterochromatin; sesame; h3t11; metabolic regulation ... See more keywords
Regulation of telomere silencing by the core histones–autophagy–Sir2 axis
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DOI: 10.26508/lsa.202201614
Abstract: This work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere… read more here.
Keywords: sir2 axis; core histones; histones autophagy; autophagy sir2 ... See more keywords