Abstract 4143: Enhancing adaptive immune responses with telomerase-mediated telomere targeting therapeutics in hepatocellular carcinoma
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DOI: 10.1158/1538-7445.am2023-4143
Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is the third leading cause of cancer-related deaths. In recent years, immune checkpoint inhibitors (ICIs) have improved treatment of solid tumors… read more here.
Keywords: mediated telomere; hepatocellular carcinoma; telomere targeting; telomerase mediated ... See more keywords
Abstract CT050: A phase 2, multi-center, open-label, dose-finding study evaluating telomere targeting agent THIO sequenced with cemiplimab in patients with advanced NSCLC
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DOI: 10.1158/1538-7445.am2023-ct050
Abstract: Background: The modified nucleoside 6-thio-2'-deoxyguanosine (THIO) is a first-in-class direct telomere-targeting agent that is preferentially incorporated in telomeres of telomerase-positive cells, leading to telomere uncapping and cancer cell death. Preclinical evidence indicates that THIO pretreatment… read more here.
Keywords: telomere targeting; targeting agent; patients advanced; thio ... See more keywords
Telomere Targeting Approaches in Cancer: Beyond Length Maintenance
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DOI: 10.3390/ijms23073784
Abstract: Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms… read more here.
Keywords: targeting approaches; telomere targeting; maintenance; approaches cancer ... See more keywords