The Molecular Mechanisms and Therapeutic Prospects of Alternative Lengthening of Telomeres (ALT)
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DOI: 10.3390/cancers15071945
Abstract: Simple Summary This review summarizes the current understanding of the telomere maintenance mechanism known as the Alternative Lengthening of Telomeres (ALT). The role, recognizable indicators, and proposed mechanism of the ALT pathway in sustaining cancer… read more here.
Keywords: telomeres alt; alt pathway; lengthening telomeres; molecular mechanisms ... See more keywords
Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)
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DOI: 10.3390/ijms19020606
Abstract: Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of replications. During tumorigenesis, cells have to acquire telomere DNA maintenance mechanisms (TMMs) in order to counteract telomere shortening, to preserve telomeres from… read more here.
Keywords: telomerase; maintenance; telomeres alt; alternative lengthening ... See more keywords