G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00545-y
Abstract: DNA or RNA strands that are composed stretches of guanines (G-tracts) divided by other bases are able to form Gquadruplexes, a tetra-helical structure with stacked G-tetrad planes connected by Hoogsteen hydrogen bonds and stabilized by… read more here.
Keywords: structures formed; human telomeric; dna; telomeric dna ... See more keywords
Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.045
Abstract: Telomeric G-quadruplex topology has the ability to regulate telomerase activity, which counteracts the shortening of telomere with successive cell divisions, thereby causing genomic longevity. However, the detailed mechanism of G-quadruplexes topologies formed by telomeric sequences… read more here.
Keywords: hydroxyl groups; topology; quadruplex topology; telomeric dna ... See more keywords
Origin of Ion Specificity of Telomeric DNA G-Quadruplexes Investigated by Free-Energy Simulations.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.04.036
Abstract: Telomeric DNA consists of tandem repeats of the sequence d(TTAGGG) that form G-quadruplex structures made of stacked guanines with monovalent cations bound at a central cavity. Although different ions can stabilize a G-quadruplex structure, the… read more here.
Keywords: telomeric dna; dna; topology; ion ... See more keywords
Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.7b00226
Abstract: We have carried out a series of extended unbiased molecular dynamics (MD) simulations (up to 10 μs long, ∼162 μs in total) complemented by replica-exchange with the collective variable tempering (RECT) approach for several human… read more here.
Keywords: propeller loops; human telomeric; force field; telomeric dna ... See more keywords
Effect of a single repeat sequence of the human telomere d(TTAGGG) on structure of single-stranded telomeric DNA d[AGGG(TTAGGG)6]
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Chemical Physics"
DOI: 10.1063/1674-0068/31/cjcp1804069
Abstract: The structures of human telomeric DNA have received much attention due to its significant biological importance. Most studies have focused on G-quadruplex structure formed by short telomeric DNA sequence, but little is known about the… read more here.
Keywords: single stranded; telomeric dna; dna; ttaggg ... See more keywords
Dynamic folding and accessibility of telomeric overhang
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211219119
Abstract: The evolution of linear chromosomes in eukaryotes poses several challenges for the natural ends of chromosomes, such as misrecognition as DNA damage repair (DDR) sites, DNA degradation, and incomplete DNA replication. A solution to these… read more here.
Keywords: single stranded; dna; accessibility; accessibility telomeric ... See more keywords
Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa479
Abstract: Abstract The dynamic topological structure of telomeric DNA is closely related to its biological function; however, no such structural information on full-length telomeric DNA has been reported due to difficulties synthesizing long double-stranded telomeric DNA.… read more here.
Keywords: single molecule; telomeric dna; stranded telomeric; double stranded ... See more keywords
Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab416
Abstract: Abstract Telomeres are copied and reassembled each cell division cycle through a multistep process called telomere replication. Most telomeric DNA is duplicated semiconservatively during this process, but replication forks frequently pause or stall at telomeres… read more here.
Keywords: budding yeast; telomeric dna; dna; dna replication ... See more keywords
Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab755
Abstract: Abstract The final 3′-terminal residue of the telomeric DNA G-overhang is inherently less precise. Here, we describe how alteration of the last 3′-terminal base affects the mutual recognition between two different G-rich oligomers of human… read more here.
Keywords: two coexisting; loop progressions; telomeric dna; pseudo mirror ... See more keywords
Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab965
Abstract: Abstract Loss of telomeric DNA leads to telomere uncapping, which triggers a persistent, p53-centric DNA damage response that sustains a stable senescence-associated proliferation arrest. Here, we show that in normal cells telomere uncapping triggers a… read more here.
Keywords: telomeric dna; dna; homologous recombination; senescence ... See more keywords
Quantification of 8-oxoG in Plant Telomeres
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094990
Abstract: Chemical modifications in DNA impact gene regulation and chromatin structure. DNA oxidation, for example, alters gene expression, DNA synthesis and cell cycle progression. Modification of telomeric DNA by oxidation is emerging as a marker of… read more here.
Keywords: oxog plant; dna; plant telomeres; oxog ... See more keywords