Experimental and In Silico Analysis of TEM β-Lactamase Adaptive Evolution
Sign Up to like & getrecommendations! Published in 2022 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00216
Abstract: Multiple mutations often have non-additive (epistatic) phenotypic effects. Epistasis is of fundamental biological relevance but is not well understood mechanistically. Adaptive evolution, i.e., the evolution of new biochemical activities, is rich in epistatic interactions. To… read more here.
Keywords: tem lactamase; gof mutations; evolution; epistasis ... See more keywords
Mutations Utilize Dynamic Allostery to Confer Resistance in TEM-1 β-lactamase
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19123808
Abstract: β-lactamases are enzymes produced by bacteria to hydrolyze β-lactam antibiotics as a common mechanism of resistance. Evolution in such enzymes has been rendering a wide variety of antibiotics impotent, therefore posing a major threat. Clinical… read more here.
Keywords: utilize dynamic; dynamic coupling; tem lactamase; resistance ... See more keywords