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   Articles with "temocillin" as a keyword



Appropriate dosing regimen of temocillin in patients with underlying kidney diseases: a retrospective study at a large District Hospital in the UK

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recommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dky449

Abstract: Sir, We read with great interest the publication by Miranda Bastos et al. regarding the dosing of temocillin in patients undergoing haemodialysis. The authors developed a population model on temocillin pharmacokinetics (PK) in haemodialysis patients… read more here.

Keywords: kidney diseases; temocillin; egfr min; infection ... See more keywords

Evaluation of temocillin for phenotypic carbapenemase screening of Escherichia coli and Salmonella enterica isolates in relation to the presence of genes encoding ESBLs and carbapenemase production

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recommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dky493

Abstract: BACKGROUND The expression of enzymes of the OXA-48 carbapenemase group is difficult to detect by phenotypic methods owing to frequent low levels of carbapenem resistance and negative results with some screening methods. Temocillin has been… read more here.

Keywords: carbapenemase; phenotypic; genes encoding; relation presence ... See more keywords

Pharmacokinetic/pharmacodynamic optimization of temocillin treatment against CTX-M-15-producing Klebsiella pneumoniae isolates in a hollow-fiber infection model

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recommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00946-25

Abstract: ABSTRACT Temocillin, a β-lactam antibiotic, has been proposed as an alternative to carbapenems for the treatment of ESBL-producing Enterobacteriaceae. The present EUCAST breakpoints for temocillin are established based on exposure levels derived from a dosing… read more here.

Keywords: ctx producing; hollow fiber; klebsiella pneumoniae; temocillin ... See more keywords

Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic

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recommendations! Published in 2022 at "Antibiotics"

DOI: 10.3390/antibiotics11040493

Abstract: Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing Enterobacterales and uncomplicated UTI due to KPC-producers. In this narrative review,… read more here.

Keywords: stewardship potential; applications antimicrobial; carbapenem; temocillin applications ... See more keywords