Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes
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DOI: 10.1021/jacs.6b09760
Abstract: Origins of life hypotheses often invoke a transitional phase of nonenzymatic template-directed RNA replication prior to the emergence of ribozyme-catalyzed copying of genetic information. Here, using NMR and ITC, we interrogate the binding affinity of… read more here.
Keywords: affinity; template; gmp; primer template ... See more keywords