The SARS-CoV-2 subgenome landscape and its novel regulatory features
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.02.036
Abstract: COVID-19, caused by Coronavirus SARS-CoV-2, is now in global pandemic. Coronaviruses are known to generate negative subgenomes (sgRNAs) through Transcription-Regulating Sequence (TRS)-dependent template switch, but the global dynamic landscapes of coronaviral subgenomes and regulatory rules… read more here.
Keywords: regulatory features; template switch; subgenome landscape; sars cov ... See more keywords
Thousands of human mutation clusters are explained by short-range template switching
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/2021.11.26.470150
Abstract: Variation within human genomes is unevenly distributed, and variants show spatial clustering. DNA- replication-related template switching is a poorly known mutational mechanism capable of causing major chromosomal rearrangements as well as creating short inverted sequence… read more here.
Keywords: short read; template; template switching; template switch ... See more keywords