Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.02.018
Abstract: Therapies with both immunomodulatory and neuroprotective properties are thought to have the greatest promise in reducing the severity and progression of multiple sclerosis (MS). Several reactive oxygen (ROS) and reactive nitrogen species (RNS) are implicated… read more here.
Keywords: tempol; disease; severity; multiple sclerosis ... See more keywords
Utilization of the nitroxyl radical TEMPOL to assess scavenging activities of lipid-soluble antioxidants against radicals initiated by the thermal decomposition of 2,2’-azobis(2,4-dimethylvaleronitrile) (AMVN) in ethanol
Sign Up to like & getrecommendations! Published in 2025 at "Free Radical Research"
DOI: 10.1080/10715762.2025.2531978
Abstract: Abstract To develop a simple and sensitive method for assessing the radical-scavenging activity of lipophilic antioxidants, the decay of the electron spin resonance (ESR) signal of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl radical (TEMPOL) was investigated as an indicator of… read more here.
Keywords: radical tempol; azobis dimethylvaleronitrile; signal decay; tempol ... See more keywords
Tempol, a Superoxide Dismutase Mimetic, Inhibits Wallerian Degeneration Following Spinal Cord Injury by Preventing Glutathione Depletion and Aldose Reductase Activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurotrauma"
DOI: 10.1089/neu.2024.0137
Abstract: Spinal cord contusion injury results in Wallerian degeneration of spinal cord axonal tracts, which are necessary for locomotor function. Axonal swelling and loss of axonal density at the contusion site, characteristic of Wallerian degeneration, commence… read more here.
Keywords: spinal cord; glutathione; degeneration; tempol ... See more keywords
Tempol Decreases Mean Arterial Pressure in Hypertensive Western Diet-Fed Hyperandrogenemic Females
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.0562
Abstract: Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and major cause of hyperandrogenemia in women. PCOS women are at increased risk of cardiovascular diseases and hypertension (HTN). Obesity aggravates the cardiometabolic phenotype in… read more here.
Keywords: pressure; age; physiology; haf ... See more keywords
The superoxide dismutase mimetic tempol does not alleviate glucocorticoid‐mediated rarefaction of rat skeletal muscle capillaries
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13243
Abstract: Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid‐induced oxidative stress contributes to this phenomenon. In rats that were implanted… read more here.
Keywords: skeletal muscle; tempol; muscle; cort ... See more keywords
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2018.31716.7714
Abstract: Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and oxidative stress, with its role… read more here.
Keywords: lung injury; inflammation; tempol; oxidative stress ... See more keywords
Tempol Ameliorates and Prevents Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2016.00532
Abstract: Chemotherapy-induced neuropathic pain is difficult to treat and prevent. Tempol decreases cellular superoxide radical levels and oxidative stress. The aims of our study were to investigate the analgesic and preventive effects of tempol on paclitaxel-induced… read more here.
Keywords: tempol; induced neuropathic; chemotherapy induced; neuropathic pain ... See more keywords
Beneficial Effect of Tempol, a Membrane-Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In Vitro Models
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11030352
Abstract: Osteoarthritis (OA) is one of the most common and widespread diseases which is highly disabling for humans. This makes OA a chronic disease for which it is urgent to find new therapeutic strategies. The inflammatory… read more here.
Keywords: tempol membrane; tempol; membrane permeable; inflammation ... See more keywords
Tempol Inhibits the Growth of Lung Cancer and Normal Cells through Apoptosis Accompanied by Increased O2•− Levels and Glutathione Depletion
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27217341
Abstract: Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable, cell-permeable redox-cycling nitroxide water-soluble superoxide dismutase (SOD) mimetic agent. However, little is known about its cytotoxic effects on lung-related cells. Thus, the present study investigated the effects of Tempol on… read more here.
Keywords: lung cancer; cancer normal; normal cells; lung ... See more keywords