Temporal Labeling of Nascent RNA Using Photoclick Chemistry in Live Cells.
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DOI: 10.1021/jacs.7b03121
Abstract: We report the first cellular application of a photoclick SPAAC reagent to label azide-functionalized RNA. 350 nm irradiation of a cyclopropenone caged oxo-dibenzocyclooctyne (photo-ODIBO) biotin yields formation of the SPAAC reactive species, which rapidly forms… read more here.
Keywords: photo odibo; rna; chemistry; nascent rna ... See more keywords