Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long‐term
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51620
Abstract: Recently, we showed that resection of at least 27% of the temporal part of piriform cortex (PiC) strongly correlated with seizure freedom 1 year following selective amygdalo‐hippocampectomy (tsSAHE) in patients with mesial temporal lobe epilepsy (mTLE).… read more here.
Keywords: long term; seizure; piriform cortex; temporal lobe ... See more keywords
Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51793
Abstract: OBJECTIVE Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline… read more here.
Keywords: white matter; brain volumes; brain; lobe epilepsy ... See more keywords
Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25180
Abstract: To evaluate the outcomes 1 year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a 5‐year period since introduction of this novel technique. read more here.
Keywords: lobe epilepsy; mesial temporal; amygdalohippocampotomy mesial; temporal lobe ... See more keywords
Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26581
Abstract: Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery. read more here.
Keywords: surgery; lobe epilepsy; rare genetic; temporal lobe ... See more keywords
Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26601
Abstract: Although growing evidence suggests that perivascular space (PVS) serves as a clearance route for amyloid and tau, the association between enlarged PVS (EPVS) and Alzheimer disease is highly inconsistent across studies. As the conventional visual… read more here.
Keywords: temporal lobe; enlarged perivascular; role enlarged; perivascular space ... See more keywords
Selective neuronal knockout of STAT3 function inhibits epilepsy progression, improves cognition, and restores dysregulated gene networks in a temporal lobe epilepsy model.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26644
Abstract: OBJECTIVE Temporal lobe epilepsy (TLE) is a progressive disorder mediated by pathological changes in molecular cascades and hippocampal neural circuit remodeling that results in spontaneous seizures and cognitive dysfunction. Targeting these cascades may provide disease-modifying… read more here.
Keywords: progression; lobe epilepsy; stat3; temporal lobe ... See more keywords
Network of ictal head version in mesial temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1820
Abstract: Ictal head version is a common clinical manifestation of mesial temporal lobe epilepsy (MTLE). Nevertheless, the location of the symptomatogenic zone and the network involved in head version remains unclear. We attempt to explain these… read more here.
Keywords: head; mesial temporal; head version; temporal lobe ... See more keywords
Characterizing white matter connectome abnormalities in patients with temporal lobe epilepsy using threshold‐free network‐based statistics
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3643
Abstract: Emerging evidence illustrates that temporal lobe epilepsy (TLE) involves network disruptions represented by hyperexcitability and other seizure‐related neural plasticity. However, these associations are not well‐characterized. Our study characterizes the whole brain white matter connectome abnormalities… read more here.
Keywords: white matter; connectome; lobe epilepsy; temporal lobe ... See more keywords
Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70935
Abstract: Temporal lobe epilepsy (TLE) is one of the most prevalent forms of epilepsy. Recent advancements in research have increasingly categorized TLE as a network disorder, focusing on its network characteristics. Prior studies predominantly examined changes… read more here.
Keywords: lobe epilepsy; temporal lobe; network; connectivity ... See more keywords
Stereological Analysis of the Rhesus Monkey Perirhinal and Parahippocampal Cortices
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25684
Abstract: The perirhinal and parahippocampal cortices are key components of the medial temporal lobe memory system. Despite their essential roles in mnemonic and perceptual functions, there is limited quantitative information regarding their structural characteristics. Here, we… read more here.
Keywords: parahippocampal cortices; temporal lobe; medial temporal; cortex ... See more keywords
Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12026
Abstract: Reproductive dysfunction is a comorbidity that commonly occurs with temporal lobe epilepsy (TLE). Characterization of this comorbidity in various models of TLE in mice will greatly facilitate mechanistic investigations of the relationship between reproductive disorders… read more here.
Keywords: cyclicity intrahippocampal; lobe epilepsy; estrous cyclicity; intrahippocampal kainic ... See more keywords